缩小差距:R 环介导的基因组不稳定性及其对神经系统疾病的影响。

IF 3 4区 医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2024-03-26 DOI:10.2217/epi-2023-0379
Katherine R Westover, Peng Jin, Bing Yao
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引用次数: 0

摘要

R 环是由 RNA-DNA 杂交体和暴露的非模板 DNA 链形成的复杂三链结构,是各种生物现象的基础。它们在细胞机制中发挥着重要而截然不同的功能,在维持细胞平衡方面发挥着关键作用。决定 R 环形成的特定细胞环境决定了它们的功能,特别强调了对它们进行细致基因组调控的必要性。值得注意的是,R 环的异常形成或失调与许多神经系统疾病有关。这篇综述重点探讨了 R 环和 DNA 双链断裂之间复杂的相互作用,探讨了 R 环失调如何可能导致各种脑部疾病的发病机制,从而为神经系统疾病进展的分子机制提供新的见解,并通过强调这些方面来确定潜在的治疗靶点。
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Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases.

R-loops, intricate three-stranded structures formed by RNA-DNA hybrids and an exposed non-template DNA strand, are fundamental to various biological phenomena. They carry out essential and contrasting functions within cellular mechanisms, underlining their critical role in maintaining cellular homeostasis. The specific cellular context that dictates R-loop formation determines their function, particularly emphasizing the necessity for their meticulous genomic regulation. Notably, the aberrant formation or misregulation of R-loops is implicated in numerous neurological disorders. This review focuses on the complex interactions between R-loops and double-strand DNA breaks, exploring how R-loop dysregulation potentially contributes to the pathogenesis of various brain disorders, which could provide novel insights into the molecular mechanisms underpinning neurological disease progression and identify potential therapeutic targets by highlighting these aspects.

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来源期刊
Epigenomics
Epigenomics GENETICS & HEREDITY-
CiteScore
5.80
自引率
2.60%
发文量
95
审稿时长
>12 weeks
期刊介绍: Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
期刊最新文献
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