利用药物基因组学结果改善他汀类药物相关的肌肉症状。

Q2 Medicine Senior Care Pharmacist Pub Date : 2024-04-01 DOI:10.4140/TCP.n.2024.151

Coral Perez González, Chandni Bardolia, Katie Pizzolato, Nishita Shah Amin

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引用次数: 0

摘要

本研究旨在证明以药物基因组学（PGx）为依据的药物审查在减轻药物不良事件（ADEs）和优化治疗效果方面的优势。药物基因组学检测和以药物基因组学为依据的用药指导有助于减轻药物不良事件（ADEs）。一位 68 岁的男性患者因慢性疼痛无法控制而接受了 PGx 检测。PGx 结果突出显示了药物与基因之间的相互作用，有助于识别他汀类药物相关肌肉症状（SAMS）导致慢性疼痛失控的风险增加。这份患者病例报告说明了结合 PGx 结果如何有助于改善慢性疼痛和减轻 ADEs（如 SAMS）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Utilizing Pharmacogenomics Results to Improve Statin-Associated Muscle Symptoms.

The objective of this aims to demonstrate the advantage of a pharmacogenomics (PGx)-informed medication review in mitigating adverse drug events (ADEs) and optimizing therapeutic outcomes. PGx testing and PGx-informed medication reviews assist in mitigating ADEs. PGx testing was performed on a 68-year-old male presenting with uncontrolled chronic pain. The PGx results highlighted a drug-gene interaction, aiding in identification of the increased risk of statin-associated muscle symptoms (SAMS) attributing to uncontrolled chronic pain. This patient case report illustrates how incorporating PGx results can help improve chronic pain and mitigate ADEs, such as SAMS.

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