紫杉类药物诱发周围神经病变的遗传决定因素。

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_31
Beata Mladosievicova, Magdalena Nemcokova Jablonicka, Lucia Tatayova, Michal Bernadic
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引用次数: 0

摘要

含紫杉类药物的治疗方案对各种癌症,尤其是卵巢癌、子宫内膜癌、乳腺癌、肺癌和前列腺癌的疗效已得到证实。然而,广泛的紫杉类药物引起的毒性限制了它们的使用。在过去的十年中,癌症患者许多毒性并发症的预测和治疗都有了长足的发展。周围神经病变是最典型的非血液类紫杉类药物相关并发症,其发病机制是多因素的。它通常与剂量有关,在治疗过程中,有时甚至在治疗后会逐渐加重。遗憾的是,对这些常见不良反应的预测仍不明确。在过去几年中,人们研究了一些可能与这种后果的发生有关的候选基因的多态性。本小节旨在强调可能增加癌症患者对紫杉类药物诱发的周围神经病变的易感性的基因预测因子的关键作用,但这些作用还未得到充分重视(参考文献 40)。关键词:紫杉醇、多西他赛、周围神经病变、风险因素、基因多态性。
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Genetic determinants of taxane-induced peripheral neuropathy.

The efficacy of taxane‑containing regimens has been demonstrated for various cancers, particularly ovarian, endometrial, breast, lung, and prostate cancers. However, extensive taxane-induced toxicities limit their use. Prediction and management of many toxic complications in cancer patients have evolved significantly over the last decade. Peripheral neuropathy is the most typical non-hematological taxane-related complication, and it has a multifactorial pathogenesis. It is often dose-dependent and progressive during therapy and sometimes even after treatment. Unfortunately, the prediction of these common adverse events remains unclear. In the past few years, several polymorphisms of candidate genes with a possible role in the development of this consequence were studied. This minireview aims to highlight the critical yet underappreciated roles of genetic predictors that may increase susceptibility to taxane-induced peripheral neuropathy in cancer patients (Ref. 40). Keywords: taxanes, paclitaxel, docetaxel, peripheral neuropathy, risk factors, genetic polymorphisms.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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