中度乙醇暴露对成年 Wistar 大鼠心血管疾病和结肠直肠癌风险因素的影响。

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Alcohol Pub Date : 2024-03-24 DOI:10.1016/j.alcohol.2024.03.010
Anna J. Kwon , Lani Morales , Louise Chatagnier , Jacqueline Quigley , Jeremy Pascua , Natalie Pinkowski , Susan M. Brasser , Mee Young Hong
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引用次数: 0

摘要

尽管过去的研究提供了过量饮酒与心血管疾病(CVDs)和结肠直肠癌(CRC)风险增加有关的证据,但关于适量饮酒对这些疾病的影响的现有数据却得出了好坏参半的结果。本研究旨在调查适量饮酒对成年大鼠患心血管疾病和结肠直肠癌相关风险因素的影响。研究人员将 24 只 14 个月大的非剥夺性雄性 Wistar 大鼠随机分配到乙醇组(隔天自愿饮用 20% (v/v) 乙醇溶液)或水对照组(n = 12/组),为期 13 周。采集血液样本分析白蛋白、葡萄糖、脂肪连通素、血脂、氧化低密度脂蛋白胆固醇、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白 A1(apolipoprotein A1,载脂蛋白 A1)、C 反应蛋白(CRP)、血清胆固醇(HDL-C,HDL-C)的水平、C反应蛋白(CRP)、高移动性盒 1 组蛋白(HMGB-1)、肿瘤坏死因子-α(TNF-α)、甲状腺素、促甲状腺激素、8-氧代-2'-脱氧鸟苷(8-氧代-dG)、肝功能酶和抗氧化能力。还评估了与结肠癌发生有关的结肠基因表达。与对照组相比,乙醇处理过的大鼠的高密度脂蛋白胆固醇(HDL-C)和载脂蛋白 A1 水平明显较高。适量饮酒导致 CRP 水平明显降低,HMGB-1、TNF-α 和 8-oxo-dG 水平呈下降趋势。与对照组相比,乙醇暴露组结肠超氧化物歧化酶基因表达上调,而醛脱氢酶 2 则呈上升趋势。这些结果表明,适量饮酒有可能通过提高高密度脂蛋白胆固醇水平和抗氧化活性,减少 DNA 损伤和炎症活动,从而改善与心血管疾病和结肠癌相关的健康生物标志物。
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Effects of moderate ethanol exposure on risk factors for cardiovascular disease and colorectal cancer in adult Wistar rats

While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks. Blood samples were collected to analyze levels of albumin, glucose, adiponectin, lipids, oxidized low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apoA1), C-reactive protein (CRP), high-mobility group box 1 protein (HMGB-1), tumor necrosis factor-alpha (TNF-α), thyroxine, thyroid-stimulating hormone, 8-oxo-2′-deoxyguanosine (8-oxo-dG), liver function enzymes, and antioxidant capacity. Colonic gene expression related to colon carcinogenesis was also assessed. Ethanol-treated rats were found to have significantly higher HDL-C and apoA1 levels compared to controls. Moderate alcohol consumption led to significantly lower CRP levels and a trend for decrease in HMGB-1, TNF-α, and 8-oxo-dG levels. In the ethanol-exposed group, colonic gene expression of superoxide dismutase was upregulated while aldehyde dehydrogenase 2 showed a trend for increase compared to the control group. These results indicate that adopting a moderate approach to alcohol consumption could potentially improve health biomarkers related to CVD and CRC by increasing HDL-C levels and antioxidant activity and reducing DNA damage and inflammatory activity.

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来源期刊
Alcohol
Alcohol 医学-毒理学
CiteScore
4.60
自引率
4.30%
发文量
74
审稿时长
15.6 weeks
期刊介绍: Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.
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