D. S. Ismailova, U. S. Makhmudov, Kh. M. Bobakulov, B. Zh. Elmuradov, A. A. Kadirov, Kh. M. Shakhidoyatov, B. Tashkhodzhaev
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引用次数: 0
摘要
在丙酮氰醇存在下，通过使胞嘧啶与芳香醛反应，合成了立体异构的胞氨酰基芳基乙酸腈。结果表明，在碱性溶液中可以选择性地形成具有芳基乙腈片段 R- 和 S- 构型的胞二氨酰基苯乙酸腈。利用核磁共振光谱和 X 射线晶体结构分析确定了合成产物的绝对构型。
Synthesis and Structural Study of Cytisinylphenylacetic Acid Nitriles
Nitriles of stereoisomeric cytisinylarylacetic acids were synthesized by reacting cytisine with aromatic aldehydes in the presence of acetone cyanohydrin. Nitriles of cytisinylphenylacetic acids with the R- and S-configuration of the arylacetonitrile fragment were shown to be formed regioselectively in basic solution. The absolute configurations of the synthesized products were established using NMR spectroscopy and X-ray crystal structure analyses.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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