{"title":"具有衰老活性的药物：前景与可能的局限性","authors":"G. V. Morgunova, A. N. Khokhlov","doi":"10.3103/s0096392524600455","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The search for and testing of drugs with senolytic activity is a new direction in gerontology. The increasing number of “senescent” cells with age contributes to the development of age-related diseases and chronic non-infectious inflammation. Removing “senescent” cells or suppressing their influence on surrounding tissues seems like a logical step to improve quality of life and possibly prolong it. However, drugs with senolytic and senomorphic activity in model systems induce the development of a number of side effects in clinical trials. In this review, we discuss the main advances in senotherapy, the prospects for the use of senotherapeutics, and the limitations that researchers and clinicians may encounter.</p>","PeriodicalId":19004,"journal":{"name":"Moscow University Biological Sciences Bulletin","volume":"30 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Drugs with Senolytic Activity: Prospects and Possible Limitations\",\"authors\":\"G. V. Morgunova, A. N. Khokhlov\",\"doi\":\"10.3103/s0096392524600455\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>The search for and testing of drugs with senolytic activity is a new direction in gerontology. The increasing number of “senescent” cells with age contributes to the development of age-related diseases and chronic non-infectious inflammation. Removing “senescent” cells or suppressing their influence on surrounding tissues seems like a logical step to improve quality of life and possibly prolong it. However, drugs with senolytic and senomorphic activity in model systems induce the development of a number of side effects in clinical trials. In this review, we discuss the main advances in senotherapy, the prospects for the use of senotherapeutics, and the limitations that researchers and clinicians may encounter.</p>\",\"PeriodicalId\":19004,\"journal\":{\"name\":\"Moscow University Biological Sciences Bulletin\",\"volume\":\"30 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Moscow University Biological Sciences Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3103/s0096392524600455\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Biological Sciences Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3103/s0096392524600455","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
Drugs with Senolytic Activity: Prospects and Possible Limitations
Abstract
The search for and testing of drugs with senolytic activity is a new direction in gerontology. The increasing number of “senescent” cells with age contributes to the development of age-related diseases and chronic non-infectious inflammation. Removing “senescent” cells or suppressing their influence on surrounding tissues seems like a logical step to improve quality of life and possibly prolong it. However, drugs with senolytic and senomorphic activity in model systems induce the development of a number of side effects in clinical trials. In this review, we discuss the main advances in senotherapy, the prospects for the use of senotherapeutics, and the limitations that researchers and clinicians may encounter.
期刊介绍：
Moscow University Biological Sciences Bulletin is forum for research in all important areas of modern biology. It publishes original work on qualitative, analytical and experimental aspects of research. The scope of articles to be considered includes plant biology, zoology, ecology, evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, gerontology, developmental biology, bioinformatics, bioengineering, virology, and microbiology.
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