第 1 组 ILCs:异质性、可塑性和转录调控。

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-04-02 DOI:10.1111/imr.13327
Raki Sudan, Susan Gilfillan, Marco Colonna
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引用次数: 0

摘要

第 1 组先天性淋巴细胞(ILCs)包括 ILC1s 和自然杀伤细胞(NK 细胞),属于发育相关的先天性淋巴细胞大家族,它们缺乏重新排列的抗原特异性受体。NK 细胞和 ILC1s 都需要转录因子 T-bet 来实现系的承诺,但它们的发育和效应物成熟程序还分别依赖于 Eomes 和 Hobit。ILC1s 和 NK 细胞对快速应对感染和通过产生效应细胞因子和细胞毒性介质介导癌症免疫至关重要。ILC1 在组织中富集,因此通常被认为是组织常驻细胞,而 NK 细胞通常被认为是循环细胞。尽管 ILC1s 和 NK 细胞被认为是不同的细胞类型,但它们在表型和功能上有许多共同之处。最近采用单细胞 RNA 测序(scRNA-seq)技术进行的研究揭示了第 1 组 ILC 先前未被认识到的异质性,进一步拓宽了我们对这些细胞的认识。这些研究结果表明,不同组织和器官中的 ILC1s 有着共同的特征,但也表现出一些独特的特征,这可能源于组织印记。此外,最近利用Hobit、RORγt和多色报告小鼠进行的命运图谱研究数据也大大推进了我们对这些细胞的发育和效应成熟程序的理解。在这篇综述中,我们旨在概述小鼠第1组ILCs的基本特征,并探讨与它们的发育程序、表型异质性、可塑性和转录调控有关的最新发现。
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Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Group 1 innate lymphoid cells (ILCs), comprising ILC1s and natural killer cells (NK cells), belong to a large family of developmentally related innate lymphoid cells that lack rearranged antigen-specific receptors. NK cells and ILC1s both require the transcription factor T-bet for lineage commitment but additionally rely on Eomes and Hobit, respectively, for their development and effector maturation programs. Both ILC1s and NK cells are essential for rapid responses against infections and mediate cancer immunity through production of effector cytokines and cytotoxicity mediators. ILC1s are enriched in tissues and hence generally considered tissue resident cells whereas NK cells are often considered circulatory. Despite being deemed different cell types, ILC1s and NK cells share many common features both phenotypically and functionally. Recent studies employing single cell RNA sequencing (scRNA-seq) technology have exposed previously unappreciated heterogeneity in group 1 ILCs and further broaden our understanding of these cells. Findings from these studies imply that ILC1s in different tissues and organs share a common signature but exhibit some unique characteristics, possibly stemming from tissue imprinting. Also, data from recent fate mapping studies employing Hobit, RORγt, and polychromic reporter mice have greatly advanced our understanding of the developmental and effector maturation programs of these cells. In this review, we aim to outline the fundamental traits of mouse group 1 ILCs and explore recent discoveries related to their developmental programs, phenotypic heterogeneity, plasticity, and transcriptional regulation.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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