中心性浆液性脉络膜视网膜病变的脉络膜高通透性模式与疾病严重程度相关:CERTAIN 研究报告 2。

IF 3 3区 医学 Q1 OPHTHALMOLOGY Acta Ophthalmologica Pub Date : 2024-04-01 DOI:10.1111/aos.16679
Laurenz J. B. Pauleikhoff, Roselie M. H. Diederen, Jennifer M. Chang-Wolf, Annette C. Moll, Reinier O. Schlingemann, Elon H. C. van Dijk, Camiel J. F. Boon
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引用次数: 0

摘要

目的:吲哚青绿血管造影术(ICGA)显示的脉络膜血管高通透性(CVH)是中心性浆液性脉络膜视网膜病变(CSC)的标志性特征。我们在 CSC 中发现了三种不同的 CVH 表型:单灶脉络膜高渗透性模糊征象(uni-FISH),伴有一个 CVH 病灶区域;多个病灶 CVH 区域(multi-FISH);以及覆盖后极大部分区域的弥漫性高渗透性(DISH)。本报告研究了这些表型的分布及其与疾病慢性化迹象的关联:CERTAIN 研究是一项单中心回顾性研究,研究对象是转诊至一家大型三级转诊中心并接受超宽场 (UWF) 和 55° ICGA 检查的连续 CSC 患者。两名独立评分员根据中后期超宽场和 55° ICGA 评估 CVH 模式,第三名评分员担任裁判:在 91 名患者的 167 只眼睛中,有 43 只(26%)显示单 FISH,87 只(52%)显示多 FISH,34 只(20%)根据 UWF ICGA 显示 DISH。中位年龄(40 岁 vs. 45 岁 vs. 57 岁;P单FISH、多FISH和DISH的CVH模式是典型的CSC模式。这些模式与已确定的 CSC 慢性化迹象相关。它们对治疗反应和预后的预测作用仍有待评估。
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Choroidal hyperpermeability patterns correlate with disease severity in central serous chorioretinopathy: CERTAIN study report 2

Purpose

Choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA) is a hallmark feature of central serous chorioretinopathy (CSC). We identified three distinct CVH phenotypes in CSC: uni-focal indistinct signs of choroidal hyperpermeability (uni-FISH) with one focal area of CVH, multiple areas of focal CVH (multi-FISH), and diffuse hyperpermeability covering most of the posterior pole (DISH). This report investigates the distribution of these phenotypes and their association with signs of disease chronicity.

Methods

The CERTAIN study is a monocentric, retrospective study on consecutive CSC patients referred to a large tertiary referral centre that underwent ultra-widefield (UWF) and 55° ICGA. Two independent graders assessed CVH patterns based on mid- to late-phase UWF and 55° ICGA with a third grader acting as referee.

Results

Of the 167 eyes of 91 patients included in this study, 43 (26%) showed uni-FISH, 87 (52%) multi-FISH, and 34 (20%) showed DISH based on UWF ICGA. Median age (40 vs. 45 vs. 57; p < 0.001) and logMAR visual acuity (0 vs. 0 vs. 0.1, p < 0.001) differed significantly in-between groups, as did the occurrence of cystoid retinal degeneration (PCRD; 0% vs. 1% vs. 18%, p < 0.001) or diffuse atrophic RPE alterations (DARA; 0% vs. 17% vs. 29%, p < 0.001). The same was true when grading was based on 55° ICGA.

Conclusions

The CVH patterns of uni-FISH, multi-FISH, and DISH are typical of CSC. These patterns correlate with established signs of CSC chronicity. Their predictive role in treatment response and prognosis remains to be evaluated.

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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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