糖皮质激素诱发的肾上腺功能不全和糖皮质激素戒断综合征：一枚硬币的两面

IF 3.4 4区医学 Q1 MEDICINE, GENERAL & INTERNAL Cleveland Clinic Journal of Medicine Pub Date : 2024-04-01 DOI:10.3949/ccjm.91a.23039

Noura Nachawi, Dingfeng Li, M Cecilia Lansang

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引用次数: 0

摘要

肾上腺疾病可导致原发性肾上腺功能不全，而下丘脑-垂体-肾上腺轴的抑制可导致继发性肾上腺功能不全（肾上腺抑制）。肾上腺抑制最常见的原因是外源性类固醇，这种情况最近被称为糖皮质激素诱发的肾上腺功能不全（GIAI）。同样，在内源性高皮质醇增多症（库欣综合征）治愈性手术后从大剂量糖皮质激素断奶或给予不足的糖皮质激素替代可导致糖皮质激素戒断综合征，这与 GIAI 重叠。

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Glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome: Two sides of the same coin.

Diseases of the adrenal glands can lead to primary adrenal insufficiency, and suppression of the hypothalamic-pituitary-adrenal axis can cause secondary adrenal insufficiency (adrenal suppression). The most common cause of adrenal suppression is exogenous steroids, a condition recently termed glucocorticoid-induced adrenal insufficiency (GIAI). Similarly, weaning from high doses of glucocorticoids or giving insufficient glucocorticoid replacement after curative surgery for endogenous hypercortisolism (Cushing syndrome) can lead to glucocorticoid withdrawal syndrome, which overlaps with GIAI.

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.