制药工艺设计和运行中的机理、数据驱动和混合建模方法的作用

IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Current Opinion in Chemical Engineering Pub Date : 2024-04-05 DOI:10.1016/j.coche.2024.101019
Mohamed Rami Gaddem , Junu Kim , Kensaku Matsunami , Yusuke Hayashi , Sara Badr , Hirokazu Sugiyama
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引用次数: 0

摘要

这篇论文以鸟瞰的视角描绘了制药行业当前的发展趋势,以及数学建模在化学工程领域质量设计框架下的工艺设计和操作中的作用。论文概述了制药行业正在采用新趋势的变革载体。数学模型的作用是伴随变革发生的基础。文章简要概述了从监管角度和工程角度对模型进行的分类,以及不同制药子领域建模的最新进展。简短的评论最后提出了在制药领域最大限度地利用建模的要点。
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Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation

This work presents a bird’s eye view depicting current trends in the pharmaceutical industry and the role of mathematical modeling in process design and operation within the framework of quality by design for a general readership in the field of chemical engineering. The paper outlines the vectors of change that are moving the pharmaceutical industry toward adopting new trends. The role of mathematical modeling is fundamental in accompanying the change taking place. A brief overview of model classification from a regulatory versus engineering point of view and recent progress in modeling in different pharmaceutical manufacturing subfields is illustrated. The short review concludes with important points to consider for maximizing the benefit of modeling in the pharmaceutical manufacturing field.

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来源期刊
Current Opinion in Chemical Engineering
Current Opinion in Chemical Engineering BIOTECHNOLOGY & APPLIED MICROBIOLOGYENGINE-ENGINEERING, CHEMICAL
CiteScore
12.80
自引率
3.00%
发文量
114
期刊介绍: Current Opinion in Chemical Engineering is devoted to bringing forth short and focused review articles written by experts on current advances in different areas of chemical engineering. Only invited review articles will be published. The goals of each review article in Current Opinion in Chemical Engineering are: 1. To acquaint the reader/researcher with the most important recent papers in the given topic. 2. To provide the reader with the views/opinions of the expert in each topic. The reviews are short (about 2500 words or 5-10 printed pages with figures) and serve as an invaluable source of information for researchers, teachers, professionals and students. The reviews also aim to stimulate exchange of ideas among experts. Themed sections: Each review will focus on particular aspects of one of the following themed sections of chemical engineering: 1. Nanotechnology 2. Energy and environmental engineering 3. Biotechnology and bioprocess engineering 4. Biological engineering (covering tissue engineering, regenerative medicine, drug delivery) 5. Separation engineering (covering membrane technologies, adsorbents, desalination, distillation etc.) 6. Materials engineering (covering biomaterials, inorganic especially ceramic materials, nanostructured materials). 7. Process systems engineering 8. Reaction engineering and catalysis.
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