雄性 Sprague Dawley 大鼠同时口服加纳苦味酒和天然可可粉前的肝肾生化指标评估

R. Maalman, S. Bimpong, C. Abaidoo, Magalys Lopez Cuba, Michael Barima Kumi, Francis Kofi Sarkodie
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摘要

引言和目的。加纳苦味酒的消费量激增。加纳苦艾酒由不少于三种植物成分浸泡而成,有机成分非常复杂。目前似乎还没有关于加纳苦艾酒对肝肾生化指标影响的研究。本研究旨在评估酒精苦味剂和可可粉对肝脏和肾脏血清生化指标的影响。材料和方法采用 24 只健康雄性 Sprague Dawley 大鼠,年龄 11-12 周,体重 150-250 克。大鼠被随机分为四组(n=6)。实验结束后,通过心脏穿刺采集血样,离心后获得血清,用于生化检测和分析。结果治疗组和对照组的肝酶无明显差异。酒精苦味剂组和天然可可粉组的总胆红素和直接胆红素平均值分别高于对照组和同时服用酒精苦味剂组和天然可可粉组。结论研究得出结论,饮用苦味酒可能会对肝脏和肾脏造成伤害,导致大鼠血清生化中的肝肾指数异常。
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Assessment of hepatorenal biochemical indices in male Sprague Dawley rats preceding concurrent oral administration of Ghana alcoholic bitters and natural cocoa powder
Introduction and aim. There has been a surge in the consumption of Ghanaian alcoholic bitters. Ghanaian alcoholic bitters are formulated from a maceration of not less than three plant parts making the organic composition very complex. There appear to be no studies on the effect of Ghanaian alcoholic bitters on the hepatorenal biochemistry indices. The study aimed to assess the effects of alcoholic bitters and cocoa powder on the liver and kidney serum biochemistry. Material and methods. Twenty-four healthy male Sprague Dawley rats, age 11–12 weeks, weighing 150–250 g were used. The rats were randomly assigned to four groups (n=6). At the end of the experimentation, a blood sample was taken by cardiac puncture and centrifuged to obtain the serum for biochemical assays and analysis. Results. The liver enzymes showed no significant difference between the treatment and control groups. There were higher mean values for total bilirubin and direct bilirubin for alcoholic bitters and natural cocoa powder groups respectively than the control group and the co-administration of alcoholic bitters and natural cocoa powder group. Conclusion. The study concludes that alcoholic bitters consumption might cause injury to the liver and kidney resulting in anomaly of the hepatorenal indices from rat blood serum biochemistry.
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