益生菌 Natupro® 成分中的芽孢杆菌对体外细菌致病菌株的影响

A. N. Ilyashenko
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摘要

相关性。益生菌对健康的益处正变得越来越流行,因为人们正在寻求更安全的产品,对疾病和传染性病原体具有保护和治疗作用。病原体中抗菌素耐药性的出现和蔓延促使人们限制非治疗性使用抗生素进行预防和促进生长,尤其是在畜牧业中。虽然单菌株益生菌对健康有益,但多菌株益生菌可能更有帮助,因为单个分离菌株之间存在协同和相加效应。本研究在体外研究了多菌株益生菌 Natupro 对致病细菌菌株(大肠杆菌 320、鼠伤寒沙门氏菌 415、金黄色葡萄球菌 12600、尤伯杯链球菌 700407、肺炎克雷伯菌 13883、单核细胞增多性李斯特菌 766/20)的有效性。研究结果表明,Natupro®中的细菌菌株对伤寒沙门氏菌415株和肺炎克雷伯氏菌13883株具有溶菌活性,对大肠埃希氏菌320株和伤寒沙门氏菌415株具有抑菌作用。
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The effect of Bacillus in the composition of the probiotic Natupro® against bacterial pathogenic strains in vitro
Relevance. The use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the nontherapeutic use of antibiotics for prophylaxis and growth promotion, especially in animal husbandry. While single-strain probiotics are beneficial to health, multi-strain probiotics might be more helpful because of synergy and additive effects among the individual isolates.Methods. In this study, the effectiveness of the multi-strain probiotic Natupro on pathogenic bacterial strains (Escherichia coli 320, Salmonella typhimurium 415, Staphylococcus aureus 12600, Streptococcus uberis 700407, Klebsiella pneumoniae 13883, Listeria monocitogenes 766/20) in vitro was studied.Results. According to the results of the work carried out, it was found that the bacterial strains in Natupro® exhibit lytic activity against pathogenic strains of Salmonella typhimurium 415 and Klebsiella pneumoniae 13883 and have a bacteriostatic effect on Escherichia coli strain 320 and Salmonella typhimurium 415.
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