双氯芬酸钠快速崩解片的设计、配方和体外评价

P. Prasanna Kumar, T. Anjali, Srinivas Nandyala, K. Sivaji
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引用次数: 0

摘要

双氯芬酸钠是一种具有消炎、解热和镇痛活性的药物。目前的研究工作是利用玉米蚕丝粉末设计和配制一种片剂,这种片剂崩解和溶解速度快,因而起效迅速,并研究其快速崩解特性。研究选择的天然聚合物具有崩解性、无毒、低成本、可靠、免费提供、生态友好、可降解和兼容性。采用直接压缩法制备了不同浓度(2-10%W/W)的玉米蚕丝粉,并进行了评估。对每个配方进行了压片前和压片后的各种参数评估,即堆积密度、压片密度、静止角、重量变化、硬度、易碎性、润湿时间、崩解时间和体外溶出度研究。体外溶出度研究表明,添加了 10%w/w 玉米丝的 F5 在 25 分钟内实现了 99.98% 的显著药物释放。
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Design, formulation and in-vitro evaluation of diclofenac sodium fast disintegrating tablets
Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been preparedCorn silkpowderwithvarious 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In- vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes.The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations.
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