脓毒症患者血清乳酸水平与存活率的相关性

Kiran Kumar Muddada
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摘要

引言败血症被定义为宿主对感染的不平衡反应导致的潜在致命性器官功能障碍。本研究的主要目的是将血清乳酸与败血症的结果联系起来。研究的次要目标是发现血清中的乳酸与败血症各种病因的关联,以及血清乳酸与败血症严重程度的关联。材料和方法:这项前瞻性横断面研究在 NRI 医学院重症监护室(ICU)和急诊科(ED)进行。研究对象包括 65 名男女患者。研究时间约为 18 个月,从 2021 年 3 月至 2022 年 9 月。研究人员进行了临床检查和血液中甘油三酯、高密度脂蛋白和空腹血糖水平的生化测试,并获得了机构伦理委员会(IEC)的许可。获得机构伦理委员会(IEC)的许可后,向患者解释了研究的相关信息。并获得了患者的书面知情同意。新开始接受抗抑郁治疗的患者将被选入精神科。研究结果在本研究中,约 69% 的患者年龄在 25 至 50 岁之间。约 28% 的患者年龄在 50 岁以上。平均年龄为 48.87 岁,标准偏差为 3.21 岁,约 65% 为男性,35% 为女性。约 77% 的患者存活。血清乳酸水平与预后之间的关系具有统计学意义(P=<0.05):脓毒症和脓毒性休克护理的基本目标是早期发现并立即进行液体复苏。
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CORRELATION OF SERUM LACTATE LEVELS WITH SURVIVAL IN PATIENTS WITH SEPSIS
Introduction: Sepsis is defined as a potentially fatal organ dysfunction caused by an unbalanced host response to infection. The primary objective of the study is to correlate serum lactate with the results of sepsis. The secondary objective of the study is to find associations of lactate in serum with the various etiological factors of sepsis and to correlate serum lactate with severity of sepsis. Material and Methods: This prospective cross-sectional study was conducted in Intensive Care Unit (ICU) and EmergencyDepartment (ED) for sepsis in NRI institute of medical sciences. A sixty five patients of both genders were included in the study. The study period were around 18 months from March 2021 to September 2022. Clinical examination and biochemical tests for blood levels of triglycerides, HDL and fasting blood glucose levels were done.Permission from Institutional Ethical Committee(IEC) were obtained. After getting permission from the Institutional Ethical Committee(IEC), information regarding the study were explained to the patients. Written and informed consent was obtained from them. Patients newly started on antidepressant treatment will be selected psychiatric department. Results: In the present study about 69%were in the age of 25 to 50 years. About 28% were in the age of more than 50 years. Only 3% were in the age of less than 25 years.Mean age is 48.87 and standard deviation is 3.21.About 65% were males and 35% were females.About 12% of patients required ventilation. About 77% survived. The relationship between serum lactate levels and outcome is statistically significant (P=<0.05) Conclusion: The fundamental goals of sepsis and septic shock care are early detection and immediate fluid resuscitation.
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