甘油三酯/高密度脂蛋白胆固醇比值在预测地震灾民入住重症监护室中的作用

Suleyman Akkaya, Ümit Çakmak
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引用次数: 0

摘要

背景:在血管和代谢疾病的研究中,甘油三酯与高密度脂蛋白胆固醇(TG/HDL)的比率至关重要。但它对地震灾民的意义尚未得到充分研究。本研究探讨了甘油三酯/高密度脂蛋白胆固醇比率与地震灾民入住重症监护室之间的关系。研究方法共纳入 64 名患者。实验室结果和临床特征均有记录。然后使用 ROC 曲线分析评估 TG/HDL 比值对入住重症监护室(ICU)的预后价值。斯皮尔曼检验用于分析 TG/HDL-c 与炎症指标之间的相关性。然后使用逻辑回归分析来阐明 TG/HDL-c 比值对入住 ICU 风险的独立贡献。研究结果组群的中位年龄为 28 岁(IQR 17-40),37 名患者(57.8%)为女性。27名患者(42.2%)住进了重症监护室。在多变量模型中,TG/HDL 比值与更高的入住 ICU 风险相关(OR:1.225,95% CI:1.003-1.496,P=0.047)。根据 ROC 曲线(AUC:0.737,95% CI:0.610-0.864,p=0.001),TG/HDL-c 比值可预测入住 ICU 的风险。TG/HDL 比值与降钙素原呈正相关(r = 0.620,p=0.001)。
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The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims
Background: In the study of vascular and metabolic diseases, the ratio of triglycerides to high-density lipoprotein (HDL) cholesterol (TG/HDL) is crucial. Its significance for earthquake victims hasn't been fully investigated, though. This study investigates the relationship between the TG/HDL ratio and critical care unit admission in earthquake victims. Methods: Sixty-four patients were enrolled. Both the laboratory results and the clinical features were documented. The TG/HDL ratio's prognostic value for intensive care unit (ICU) admission was then evaluated using ROC curve analysis. Spearman test was applied to analyze correlation between TG/HDL-c and inflammation markers. Logistic regression analysis was then used to elucidate the independent contribution of the TG/HDL-c ratio to the ICU admission risk. Results: Median age of the cohort was 28 (IQR 17-40) and thirty-seven (57.8%) of the patients were female. 27 patients (42.2%) were admitted to ICU. In the multivariate model, the TG/HDL ratio was associated with higher risk of ICU admission (OR: 1.225, 95% CI: 1.003-1.496, p=0.047). The TG/HDL-c ratio may be a predictor of ICU admissions, according to the ROC curve (AUC: 0.737, 95% CI: 0.610-0.864, p=0.001). The TG/HDL ratio was positively correlated with procalcitonin (r = 0.620, p
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