用消炎药治疗与 SARS-CoV-2 感染有关的心律紊乱

Z. Sukmarova, E. Zotkin
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摘要

有关与新型冠状病毒感染(COVID-19)相关的心律失常的文献主要集中在这种并发症的高发病率和症状上。我们没有发现任何关于治疗与 SARS-CoV2 相关的心律失常的具体研究,因为这可能意味着一种标准的治疗方法。本文描述了一系列在急性 COVID-19 背景下出现的各种心律失常病例,这些病例接受了抗炎治疗,但没有接受抗心律失常药物治疗。这些病例的共同点是发生急性 SARS-CoV-2 感染,复发与炎症症状有关,以及主要抗炎药物的治疗效果。文献综述为心律失常的炎症理论提供了依据,并为讨论如何将不同的抗炎药物纳入此类患者的治疗方案奠定了基础。
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Treatment of heart rhythm disturbances associated with SARS-CoV-2 infection with anti-inflammatory drugs
Publications regarding cardiac arrhythmias associated with the new coronavirus infection (COVID-19) focus primarily on the high prevalence and symptoms of this complication. We have not found any studies on the specific treatment of arrhythmias associated with SARS-CoV2, since a standard therapeutic approach is probably implied. This observation describes a series of cases of various cardiac arrhythmias that occurred against the background of acute COVID-19 and were treated with anti-inflammatory, but not antiarrhythmic drugs. The cases are united by the occurrence of acute SARS-CoV-2 infection, the connection of relapses with inflammation symptoms, as well as the effectiveness of therapy with the main classes of anti-inflammatory drugs. A narrative review of the literature provides the rationale for the inflammatory theory of arrhythmias and sets the stage for discussion about how to integrate differentially anti-inflammatory drugs into the treatment regimen of such patients.
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