受 9-芴甲氧羰基保护的非蛋白氨基酸的合成和体外抗菌活性研究

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY Eurasian Chemico-Technological Journal Pub Date : 2024-02-15 DOI:10.18321/ectj1546

T.H. Sargsyan, L.A. Stepanyan, M. H. Israyelyan, H.I. Hakobyan, S. M. Jamgaryan, A.A. Gasparyan, A. Saghyan

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引用次数: 0

摘要

利用 9-芴甲氧羰基保护基，开发出文献中未提及的 9-芴甲氧羰基-(S)-β-(N-咪唑基)-α-丙氨酸保护非蛋白氨基酸。然后用同样的方法合成了 9-芴甲氧羰基-(S)-α-甲基苯丙氨酸、9-芴甲氧羰基-(S)-α-烯丙基甘氨酸、9-芴甲氧羰基-(S)-α-丙基甘氨酸。结果表明，9-芴甲氧羰基-(S)-β-(N-咪唑基)-α-丙氨酸（3）能抑制革兰氏阴性沙门氏菌 G-38 的生长，9-芴甲氧羰基-(S)-α-甲基苯丙氨酸（4）能抑制革兰氏阳性枯草杆菌 17-89 的生长。

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The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity

Using the 9-fluorenylmethoxycarbonyl protecting group, 9-fluorenylmethoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine protected non-protein amino acid, not described in the literature, were developed. Then 9-fluorenylmethoxycarbonyl-(S)-α-methylphenylalanine, 9-fluorenylmethoxycarbonyl-(S)-α-allylglycine, 9-fluorenylmethoxycarbonyl-(S)-α-propargylglycine were synthesized by the same method. It was shown, that the 9-fluorenylmethoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine (3) inhibited the growth of Gram-negative Salmonella tуphimurium G-38 and 9-fluorenyl-methoxycarbonyl-(S)-α-methyl-phenylalanine (4) inhibited the growth Gram-positive Bacillus subtilis 17-89 bacteria.

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来源期刊

Eurasian Chemico-Technological Journal CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.10

自引率

20.00%

发文量

审稿时长

20 weeks

期刊介绍： The journal is designed for publication of experimental and theoretical investigation results in the field of chemistry and chemical technology. Among priority fields that emphasized by chemical science are as follows: advanced materials and chemical technologies, current issues of organic synthesis and chemistry of natural compounds, physical chemistry, chemical physics, electro-photo-radiative-plasma chemistry, colloids, nanotechnologies, catalysis and surface-active materials, polymers, biochemistry.