Advances in Neutrophil Cell Membrane-coated Nano Drug Delivery Systems: A Comprehensive Review

Cell-mediated drug delivery systems have gained significant attention in medical research due to their potential for enhanced therapeutic specificity and efficacy in various diseases. Among immune cells, neutrophils (NEs) have emerged as a promising candidate for drug delivery due to their prevalence and rapid response in inflammatory sites. However, the short lifespan and challenges associated with the in vitro cultivation of NEs have hindered their direct use for drug administration. This review aims to highlight the importance of NEs as effective drug-delivery vehicles and elucidate the underlying mechanisms contributing to their pharmacological efficacy. By analyzing recent studies and advancements in the field, we will discuss the strategies employed to harness NEs as drug carriers, including coating nanostructures with NE cell membranes. Additionally, we will explore the unique properties of NEs that enable targeted drug delivery, such as their ability to navigate through complex biological environments and actively migrate toward inflamed tissues. Furthermore, we will delve into the mechanisms of NE-mediated drug release and the potential applications of NE-based drug delivery systems in various therapeutic areas. Overall, this review provides valuable insights into the use of NEs as drug delivery mechanisms and offers perspectives on the future directions of this exciting field.