髋部骨折患者术前白蛋白-球蛋白比值与术后肺炎之间的非线性关系

Daxue Zhang , Yu Zhang , Shiwei Yang
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引用次数: 0

摘要

背景和目的术后肺炎(POP)是导致髋部骨折患者死亡的主要原因。评估这些患者的风险可以使用简单而经济的指标。本研究旨在探讨髋部骨折患者术后肺炎(POP)与术前白蛋白-球蛋白比值(AGR)之间的关联。采用广义加和逻辑回归模型确定术前 AGR 与 POP 之间的线性和非线性关系。结果该研究共纳入 1417 名参与者,平均年龄为 77.57(8.53)岁,男性患者占 26.96%(382/1417)。POP 患病率为 6.21%。经全面协变量调整后,AGR 每增加一个单位,POP 发病率就会降低 79%(OR,0.23;95% CI:0.08-0.63;P = 0.0046)。使用两件式回归模型发现拐点为 1.33。拐点左侧的 AGR 每增加一个单位,POP 的发生率就会降低 93%(OR,0.07;95%CI:0.02-0.34;P = 0.0010)。结论老年髋部骨折患者术前 AGR 与 POP 发生率之间存在非线性关系。当 AGR 小于 1.33 时,POP 的发生率与 AGR 呈负相关。但是,当 AGR 大于 1.33 时,两者之间没有相关性。
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Non-linear relationship between preoperative albumin-globulin ratio and postoperative pneumonia in patients with hip fracture

Background and objective

Postoperative pneumonia (POP) is the leading cause of death among patients with hip fractures. Simple and cost-effective markers can be used to assess the risk of these patients. This study aims to investigate the association between POP and preoperative albumin-globulin ratio (AGR) in patients with hip fractures.

Methods

A retrospective analysis was conducted on data from 1417 hip fracture patients admitted to the Department of Orthopaedics at the hospital. Generalized additive and logistic regression models were used to determine both linear and non-linear associations between preoperative AGR and POP. A two-piece regression model was employed to determine the threshold effect.

Results

The study included 1417 participants, with a mean age of 77.57 (8.53) years and 26.96% (382/1417) male patients. The prevalence of POP was 6.21%. Following full covariate adjustment, each unit increase in AGR was associated with a 79% reduction in the incidence of POP (OR, 0.23; 95% CI: 0.08–0.63; P = 0.0046). The inflection point was found to be 1.33 using a two-piecewise regression model. For each unit increase in AGR on the left side of the inflection point, the incidence of POP decreased by 93% (OR, 0.07; 95%CI: 0.02–0.34; P = 0.0010). However, there was no statistically significant correlation on the right side of the inflection point (OR, 0.84; 95% CI: 0.17–4.10; P = 0.8287).

Conclusion

There exists a non-linear association between preoperative AGR and the incidence of POP in elderly hip fracture patients. When AGR is less than 1.33, the incidence of POP is negatively correlated with AGR. However, there is no correlation when AGR is greater than 1.33.

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来源期刊
CiteScore
2.60
自引率
14.30%
发文量
34
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