Jana Klaus , Catherine J. Stoodley , Dennis J.L.G. Schutter
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An age-specific association between VIQ and GMV of bilateral Crus II was found in ASD relative to neurotypical controls. In children with ASD, higher VIQ was associated with larger GMV of left Crus II but smaller GMV of right Crus II. By contrast, in adults with ASD, higher VIQ was associated with smaller GMV of left Crus II and larger GMV of right Crus II. 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引用次数: 0
摘要
自闭症谱系障碍(ASD)是一种经常与小脑结构异常有关的神经发育疾病。小脑灰质体积(GMV)是否与言语障碍有关仍存在争议。在此,我们研究了ASD患者在整个生命周期中小脑灰质体积与言语能力之间的关系。根据ABIDE I数据集的结构性核磁共振成像扫描结果,对男性ASD患者(144人,年龄:8.5-64.0岁)和神经典型对照组(188人,年龄:8.0-56.2岁)的小脑进行小叶分割。通过逐步线性混合效应建模(包括组别(ASD vs. 神经畸形对照组)、小脑小叶GMV和年龄)来确定最能预测以言语智商(VIQ)衡量的言语能力的小脑小叶。与神经正常对照组相比,ASD 患儿的 VIQ 与双侧 Crus II 的 GMV 之间存在年龄特异性关联。在患有 ASD 的儿童中,VIQ 越高,左侧嵴椎 II 的 GMV 越大,而右侧嵴椎 II 的 GMV 越小。相比之下,在患有 ASD 的成人中,较高的 VIQ 与较小的左侧十字ⅡGMV 和较大的右侧十字ⅡGMV 相关。这些研究结果表明,相对于对侧半球而言,最初对语言无特异性的左侧小脑半球的依赖在成年后被更典型的右侧化所抵消。
Neurodevelopmental trajectories of cerebellar grey matter associated with verbal abilities in males with autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition frequently associated with structural cerebellar abnormalities. Whether cerebellar grey matter volumes (GMV) are linked to verbal impairments remains controversial. Here, the association between cerebellar GMV and verbal abilities in ASD was examined across the lifespan. Lobular segmentation of the cerebellum was performed on structural MRI scans from the ABIDE I dataset in male individuals with ASD (N=144, age: 8.5–64.0 years) and neurotypical controls (N=188; age: 8.0–56.2 years). Stepwise linear mixed effects modeling including group (ASD vs. neurotypical controls), lobule-wise GMV, and age was performed to identify cerebellar lobules which best predicted verbal abilities as measured by verbal IQ (VIQ). An age-specific association between VIQ and GMV of bilateral Crus II was found in ASD relative to neurotypical controls. In children with ASD, higher VIQ was associated with larger GMV of left Crus II but smaller GMV of right Crus II. By contrast, in adults with ASD, higher VIQ was associated with smaller GMV of left Crus II and larger GMV of right Crus II. These findings indicate that relative to the contralateral hemisphere, an initial reliance on the language-nonspecific left cerebellar hemisphere is offset by more typical right-lateralization in adulthood.
期刊介绍:
The journal publishes theoretical and research papers on cognitive brain development, from infancy through childhood and adolescence and into adulthood. It covers neurocognitive development and neurocognitive processing in both typical and atypical development, including social and affective aspects. Appropriate methodologies for the journal include, but are not limited to, functional neuroimaging (fMRI and MEG), electrophysiology (EEG and ERP), NIRS and transcranial magnetic stimulation, as well as other basic neuroscience approaches using cellular and animal models that directly address cognitive brain development, patient studies, case studies, post-mortem studies and pharmacological studies.