{"title":"使用烯丙基烷基化方法全合成莫伊酰胺 B","authors":"","doi":"10.1055/s-0042-1751578","DOIUrl":null,"url":null,"abstract":"An allylic side chain is introduced onto a chiral γ-amino-β-ketoamide by a Pd-catalyzed allylic alkylation. Subsequent ozonolysis and oxidation proceed only with Cbz-protected ketoamides. The total synthesis of moiramide B is finalized by peptide coupling.","PeriodicalId":22319,"journal":{"name":"Synlett","volume":"38 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Total Synthesis of Moiramide B Using an Allylic Alkylation Approach\",\"authors\":\"\",\"doi\":\"10.1055/s-0042-1751578\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An allylic side chain is introduced onto a chiral γ-amino-β-ketoamide by a Pd-catalyzed allylic alkylation. Subsequent ozonolysis and oxidation proceed only with Cbz-protected ketoamides. The total synthesis of moiramide B is finalized by peptide coupling.\",\"PeriodicalId\":22319,\"journal\":{\"name\":\"Synlett\",\"volume\":\"38 1\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synlett\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0042-1751578\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synlett","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1055/s-0042-1751578","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
摘要
通过钯催化的烯丙基烷基化反应，在手性 γ-氨基-β-酮酰胺上引入了烯丙基侧链。只有 Cbz 保护的酮酰胺才能进行后续的臭氧分解和氧化。最后通过肽偶联完成莫来酰胺 B 的全合成。
Total Synthesis of Moiramide B Using an Allylic Alkylation Approach
An allylic side chain is introduced onto a chiral γ-amino-β-ketoamide by a Pd-catalyzed allylic alkylation. Subsequent ozonolysis and oxidation proceed only with Cbz-protected ketoamides. The total synthesis of moiramide B is finalized by peptide coupling.
期刊介绍：
SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
