通过保护性穿透角膜移植术提高手术安全性:22 例病例的回顾性分析

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY Journal of Ophthalmology Pub Date : 2024-04-05 DOI:10.1155/2024/2718527
Tian Yang, Miguel O. M. Castellanos
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引用次数: 0

摘要

背景。穿透性角膜成形术(PK)是一种公认的角膜损伤治疗方法,但也存在固有风险,主要是由于其开放性,有可能导致严重的危及视力的并发症。保护性穿透角膜移植术(PPK)作为一种新型手术应运而生,旨在降低这些风险。目的通过对 22 例病例的回顾性分析,评估手术安全性、术后效果以及 PPK 对角膜内皮细胞密度的影响。设置与设计。2018年2月至2021年12月,在Hermanos Ameijeiras医院开展了一项回顾性横断面观察研究,共涉及22名患者(22只眼),这些患者对其他药物治疗无反应,矫正远视力≤0.1。方法和材料。患者接受了 PPK,手术过程和术后护理均有记录。对定性和定量变量进行统计分析,以评估手术效果和术后角膜内皮细胞密度的变化。结果。所有手术的术后视力均有明显改善(),12个月时角膜内皮细胞密度下降了9.2%。值得注意的并发症包括一例术中发现的触点脱位和一例术后细菌性角膜炎。结论。PPK 有可能减轻围手术期并发症,确保移植角膜的清晰度,减少角膜内皮细胞的损失,是传统 PK 的可行替代方案。虽然研究结果令人鼓舞,但要在更广泛的临床环境中验证 PPK 的益处和适用性,还需要进行更大规模的研究。
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Enhanced Surgical Safety through Protective Penetrating Keratoplasty: A Retrospective Analysis of 22 Cases
Context. Penetrating keratoplasty (PK) is a recognized treatment for corneal damage but possesses inherent risks, mainly due to its open-sky nature, which potentially lead to severe sight-threatening complications. Protective penetrating keratoplasty (PPK) emerges as a novel procedure aimed at mitigating these risks. Aim. To assess the surgical safety, postoperative outcomes, and the impact of PPK on corneal endothelial cell density through a retrospective analysis of 22 cases. Settings and Design. A retrospective cross-sectional observational study was executed at Hermanos Ameijeiras Hospital from February 2018 to December 2021, involving 22 patients (22 eyes) who were unresponsive to other medical treatments and had a corrected distance visual acuity of ≤0.1. Methods and Materials. Patients underwent PPK, with surgical procedures and postoperative care documented. Statistical analysis was performed on qualitative and quantitative variables to evaluate the surgical outcomes and the corneal endothelial cell density changes postoperation. Results. All surgeries demonstrated a significant improvement in postoperative visual acuity () and recorded a 9.2% decrease in the corneal endothelial cell density at 12 months. Noteworthy complications included one case of intraoperatively discovered haptic dislocation and one postoperative bacterial keratitis. Conclusions. PPK could potentially mitigate perioperative complications, ensure graft clarity, and reduce corneal endothelial cell loss, presenting itself as a viable alternative to traditional PK. Although the results are encouraging, larger-scale studies are essential to validate the benefits and applicability of PPK in broader clinical settings.
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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