上皮-间质转化过程中的加连蛋白:促进组织修复、纤维化和癌症转移的作用和机制

IF 4.3 2区 生物学 Q1 BIOLOGY Biological Research Pub Date : 2024-04-04 DOI:10.1186/s40659-024-00490-5
Elisa Perez-Moreno, Claudia Oyanadel, Adely de la Peña, Ronny Hernández, Francisca Pérez-Molina, Claudia Metz, Alfonso González, Andrea Soza
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引用次数: 0

摘要

凝集素是一种可溶性糖结合蛋白,能与多种糖蛋白和糖脂相互作用,并能调节多种生理和病理过程。在组织修复、纤维化和癌变过程中,上皮细胞会失去分化能力,同时获得迁移性间充质表型,不同组织和细胞类型的上皮细胞会失去分化能力,同时获得迁移性间充质表型。在这些过程中发生的上皮-间充质转化(EMT)可能包括糖脂和糖蛋白糖基化模式的改变,从而影响它们与半连接蛋白的相互作用。此外,某些 galectins 的过度表达也与 EMT 的发展和不同结果有关。本综述将重点讨论 Galectin-1(Gal-1)、Gal-3、Gal-4、Gal-7 和 Gal-8 在生理性和致病性 EMT 中的作用和机制。
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Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts.
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来源期刊
Biological Research
Biological Research 生物-生物学
CiteScore
10.10
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: Biological Research is an open access, peer-reviewed journal that encompasses diverse fields of experimental biology, such as biochemistry, bioinformatics, biotechnology, cell biology, cancer, chemical biology, developmental biology, evolutionary biology, genetics, genomics, immunology, marine biology, microbiology, molecular biology, neuroscience, plant biology, physiology, stem cell research, structural biology and systems biology.
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