{"title":"牧野蛇床子根茎中具有促进细胞内甘油三酯代谢活性的烷基酞类化合物","authors":"Toshio Morikawa, Naoki Inoue, Saya Yamamoto, Miyuki Shiotani, Yoshiaki Manse, Kiyofumi Ninomiya","doi":"10.1007/s11418-024-01799-x","DOIUrl":null,"url":null,"abstract":"<div><p>Methanol extract of the <i>Cnidium officinale</i> Makino rhizome, which is used as a crude drug Cnidium Rhizome (<i>Cnidii Rhizoma</i>; “<i>Senkyu</i>” in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells. Thirty-five constituents, including two new alkylphthalide glycosides, senkyunosides A (<b>1</b>) and B (<b>2</b>), and a neolignan with a new stereoisomeric structure (<b>3</b>), were isolated in the extract. Their stereostructures were elucidated based on chemical and spectroscopic evidence. Among the isolates, several alkylphthalides, (<i>Z</i>)-3-butylidene-7-methoxyphthalide (<b>9</b>) and senkyunolides G (<b>10</b>), H (<b>14</b>), and I (<b>15</b>), and a polyacetylene falcarindiol (<b>26</b>), were found to show significant activity without any cytotoxicity at 10 μM.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"78 3","pages":"709 - 721"},"PeriodicalIF":2.5000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-024-01799-x.pdf","citationCount":"0","resultStr":"{\"title\":\"Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino\",\"authors\":\"Toshio Morikawa, Naoki Inoue, Saya Yamamoto, Miyuki Shiotani, Yoshiaki Manse, Kiyofumi Ninomiya\",\"doi\":\"10.1007/s11418-024-01799-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Methanol extract of the <i>Cnidium officinale</i> Makino rhizome, which is used as a crude drug Cnidium Rhizome (<i>Cnidii Rhizoma</i>; “<i>Senkyu</i>” in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells. Thirty-five constituents, including two new alkylphthalide glycosides, senkyunosides A (<b>1</b>) and B (<b>2</b>), and a neolignan with a new stereoisomeric structure (<b>3</b>), were isolated in the extract. Their stereostructures were elucidated based on chemical and spectroscopic evidence. Among the isolates, several alkylphthalides, (<i>Z</i>)-3-butylidene-7-methoxyphthalide (<b>9</b>) and senkyunolides G (<b>10</b>), H (<b>14</b>), and I (<b>15</b>), and a polyacetylene falcarindiol (<b>26</b>), were found to show significant activity without any cytotoxicity at 10 μM.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":654,\"journal\":{\"name\":\"Journal of Natural Medicines\",\"volume\":\"78 3\",\"pages\":\"709 - 721\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s11418-024-01799-x.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11418-024-01799-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11418-024-01799-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino
Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; “Senkyu” in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells. Thirty-five constituents, including two new alkylphthalide glycosides, senkyunosides A (1) and B (2), and a neolignan with a new stereoisomeric structure (3), were isolated in the extract. Their stereostructures were elucidated based on chemical and spectroscopic evidence. Among the isolates, several alkylphthalides, (Z)-3-butylidene-7-methoxyphthalide (9) and senkyunolides G (10), H (14), and I (15), and a polyacetylene falcarindiol (26), were found to show significant activity without any cytotoxicity at 10 μM.
期刊介绍：
The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers:
-chemistry of natural products
-biochemistry of medicinal plants
-pharmacology of natural products and herbs, including Kampo formulas and traditional herbs
-botanical anatomy
-cultivation of medicinal plants.
The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
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