营养保健品口服薄膜时代的来临:从实验室到临床

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-04-12 DOI:10.1016/j.biotechadv.2024.108362
Ruchika , Nabab Khan , Shagun Sanjivv Dogra , Ankit Saneja
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引用次数: 0

摘要

口服薄膜(OTF)是一种创新剂型,在营养保健品的给药方面获得了极大的关注。它们是超薄、柔韧的薄片,可以很容易地放在舌头、舌下或颊粘膜(颊内壁)上。这些薄膜在营养保健品的给药方面具有多种优势,包括给药方便、崩解迅速、吸收快、起效快、可绕过肝脏的首过代谢、剂量准确、稳定性更强、便于携带、隐蔽性好、剂量灵活,最重要的是消费者接受度高。本综述重点介绍了利用 OTFs 给药的营养保健品、其成分、辅料选择标准、开发方法和基于质量的设计(QbD)方法,以实现优质产品。我们还提供了最新的案例研究,展示了 OTF 作为营养保健品(植物提取物、生物活性分子、维生素、矿物质和蛋白质/肽)和益生菌递送平台的前景。最后,我们介绍了与这种独特剂型相关的技术进步、最新专利、市场分析、挑战和未来展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The dawning era of oral thin films for nutraceutical delivery: From laboratory to clinic

Oral thin films (OTFs) are innovative dosage forms that have gained tremendous attention for the delivery of nutraceuticals. They are ultra-thin, flexible sheets that can be easily placed on the tongue, sublingual or buccal mucosa (inner lining of the cheek). These thin films possess several advantages for nutraceutical delivery including ease of administration, rapid disintegration, fast absorption, rapid onset of action, bypass first-pass hepatic metabolism, accurate dosing, enhanced stability, portability, discreetness, dose flexibility and most importantly consumer acceptance. This review highlights the utilization OTFs for nutraceutical delivery, their composition, criteria for excipient selection, methods of development and quality-based design (QbD) approach to achieve quality product. We have also provided recent case studies representing OTFs as promising platform in delivery of nutraceuticals (plant extracts, bioactive molecules, vitamins, minerals and protein/peptides) and probiotics. Finally, we provided advancement in technologies, recent patents, market analysis, challenges and future perspectives associated with this unique dosage form.

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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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