在内科病房对 COVID-19 患者进行系统的曲霉菌病血清筛查是否有意义？

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES Infectious diseases now Pub Date : 2024-04-16 DOI:10.1016/j.idnow.2024.104918

Victor Gerber , Louis Boehn , Marcela Sabou , Antoine Studer , Axel Ursenbach , Yves Hansmann , Raoul Herbrecht , Nicolas Lefebvre , Valérie Letscher-Bru , François Danion

{"title":"在内科病房对 COVID-19 患者进行系统的曲霉菌病血清筛查是否有意义？","authors":"Victor Gerber , Louis Boehn , Marcela Sabou , Antoine Studer , Axel Ursenbach , Yves Hansmann , Raoul Herbrecht , Nicolas Lefebvre , Valérie Letscher-Bru , François Danion","doi":"10.1016/j.idnow.2024.104918","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>We evaluated the interest of systematic screening of serum fungal markers in patients hospitalized in a medical ward.</p></div><div><h3>Methods</h3><p>We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed.</p></div><div><h3>Results</h3><p>Thirty patients were included. The majority of patients received corticosteroids (96.7%). The galactomannan antigen assay was positive for 1/30 patients at D0, and 0/24, 0/16, 0/13 and 0/2 at D4, D7, D10 and D14 respectively. 1,3-ß-D-glucan was positive for 0/30, 1/24, 1/12, 0/12, 0/2 at D0, D4, D7, D10 and D14 respectively. No <em>Aspergillus fumigatus</em> PCR was positive. No cases of aspergillosis were retained.</p></div><div><h3>Conclusion</h3><p>Our study does not support the interest of systematic screening of fungal markers in immunocompetent patients with COVID-19 in a conventional unit.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000757/pdfft?md5=6625c2ae90df49374a4facefa0017fee&pid=1-s2.0-S2666991924000757-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Is there an interest in systematic serum screening for aspergillosis in COVID-19 patients in a medical ward?\",\"authors\":\"Victor Gerber , Louis Boehn , Marcela Sabou , Antoine Studer , Axel Ursenbach , Yves Hansmann , Raoul Herbrecht , Nicolas Lefebvre , Valérie Letscher-Bru , François Danion\",\"doi\":\"10.1016/j.idnow.2024.104918\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>We evaluated the interest of systematic screening of serum fungal markers in patients hospitalized in a medical ward.</p></div><div><h3>Methods</h3><p>We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed.</p></div><div><h3>Results</h3><p>Thirty patients were included. The majority of patients received corticosteroids (96.7%). The galactomannan antigen assay was positive for 1/30 patients at D0, and 0/24, 0/16, 0/13 and 0/2 at D4, D7, D10 and D14 respectively. 1,3-ß-D-glucan was positive for 0/30, 1/24, 1/12, 0/12, 0/2 at D0, D4, D7, D10 and D14 respectively. No <em>Aspergillus fumigatus</em> PCR was positive. No cases of aspergillosis were retained.</p></div><div><h3>Conclusion</h3><p>Our study does not support the interest of systematic screening of fungal markers in immunocompetent patients with COVID-19 in a conventional unit.</p></div>\",\"PeriodicalId\":13539,\"journal\":{\"name\":\"Infectious diseases now\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666991924000757/pdfft?md5=6625c2ae90df49374a4facefa0017fee&pid=1-s2.0-S2666991924000757-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious diseases now\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666991924000757\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases now","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666991924000757","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

方法我们回顾性分析了 2020 年 10 月 1 日至 10 月 31 日期间因 COVID-19 在我院感染性疾病科住院的所有患者，这些患者事先未入住 ICU，并对其进行了血清真菌标志物系统筛查。大多数患者接受了皮质类固醇治疗（96.7%）。半乳甘露聚糖抗原检测在 D0 时有 1/30 患者呈阳性，在 D4、D7、D10 和 D14 时分别为 0/24、0/16、0/13 和 0/2。1,3-ß-D-葡聚糖在 D0、D4、D7、D10 和 D14 时分别有 0/30、1/24、1/12、0/12 和 0/2 呈阳性。没有曲霉菌 PCR 呈阳性。结论：我们的研究并不支持在常规病房对免疫功能正常的 COVID-19 患者进行系统的真菌标记物筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Is there an interest in systematic serum screening for aspergillosis in COVID-19 patients in a medical ward?

Purpose

We evaluated the interest of systematic screening of serum fungal markers in patients hospitalized in a medical ward.

Methods

We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed.

Results

Thirty patients were included. The majority of patients received corticosteroids (96.7%). The galactomannan antigen assay was positive for 1/30 patients at D0, and 0/24, 0/16, 0/13 and 0/2 at D4, D7, D10 and D14 respectively. 1,3-ß-D-glucan was positive for 0/30, 1/24, 1/12, 0/12, 0/2 at D0, D4, D7, D10 and D14 respectively. No Aspergillus fumigatus PCR was positive. No cases of aspergillosis were retained.