在越南北部发现新的 HIV-1 CRF127_07109 循环重组形式。

IF 1.5 4区医学 Q4 IMMUNOLOGY AIDS research and human retroviruses Pub Date : 2024-04-26 DOI:10.1089/AID.2024.0022

Tsunefusa Hayashida, Linh Khanh Tran, An Luong-Dieu Dang, Moeko Nagai, Shoko Matsumoto, Hoa Nguyen-Minh Le, T. D. Van, Giang Van Tran, J. Tanuma, Thach Ngoc Pham, Shinichi Oka

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引用次数: 0

摘要

在我们之前的研究中，在越南北部发现了一些新的循环重组型（CRF）HIV-1 候选者。我们利用 MinION 成功地对 12 名 HIV 感染者的血浆样本进行了近全长测序。其中三个样本是最近在中国报道的 CRF109_0107。另外三个是新发现的CRF127_07109，而其中六个被认为是与CRF127_07109相关的独特重组形式（URF）。据估计，CRF127_07109的最近共同祖先的时间在2015年至2019年之间。我们的研究结果表明，CRF127_07109和相关的URF是最近在越南北部产生的，而不是独立迁移到越南北部的。

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Identification of New Circulating Recombinant Form of HIV-1 CRF127_07109 in Northern Vietnam.

Some candidates of a new circulating recombinant form (CRF) of HIV-1 were found in northern Vietnam in our previous study. We succeeded in near full-length sequencing using MinION with plasma samples from 12 people living with HIV. Three of the samples were CRF109_0107, which was recently reported in China. Three others were the newly identified CRF127_07109, while six of them were considered to be CRF127_07109-related unique recombinant forms (URFs). The time to the most recent common ancestor of CRF127_07109 was estimated to be between 2015 and 2019. Our findings showed that CRF127_07109 and related URFs were generated recently in northern Vietnam, rather than migrated independently to northern Vietnam.

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来源期刊

AIDS research and human retroviruses 医学-病毒学

CiteScore

3.10

自引率

6.70%

发文量

201

审稿时长

3-6 weeks

期刊介绍： AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.