基于聚集的分析化学在床旁纳米传感器中的应用

IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY Aggregate (Hoboken, N.J.) Pub Date : 2024-04-23 DOI:10.1002/agt2.559
Yuechun Li, Zhaowen Cui, Lunjie Huang, Daohong Zhang, Yizhong Shen, Jie Cheng, Jianlong Wang
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引用次数: 0

摘要

实现有害分析物的床旁 (POC) 检测至关重要,它能够节约有限的农业资源、协助环境修复、确保食品安全并实现早期疾病诊断。与其他传统的 POC 传感策略相比,基于聚集的分析化学通过来自目标的多种聚集诱导 "力 "的作用,改变纳米探针的聚集状态,从而促进了以实用为导向的 POC 纳米传感器的开发。在此,我们对基于聚集的分析化学在 POC 纳米传感器中的应用进行了全面综述,内容包括聚集诱导的 "力"、聚集诱导的信号转导、聚集诱导的 POC 纳米传感策略及其在生物分子监测、食品安全分析和环境监测中的应用。最后,我们进一步提出了在实际应用中存在的挑战,以改进其传感应用,并期望我们的综述能够通过基于聚集的分析化学,加快开发具有成本效益、可随时部署和时间效率高的纳米传感器。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Aggregation-based analytical chemistry in point-of-care nanosensors

It is crucial to realize the point-of-care (POC) testing of harmful analytes, capable of saving limited agricultural resources, assisting environmental remediation, ensuring food safety, and enabling early disease diagnosis. Compared with other conventional POC sensing strategies, aggregation-based analytical chemistry facilitates the practical-oriented development of POC nanosensors by altering the aggregation status of nanoprobes through the action of multiple aggregation-induced “forces” originating from the targets. Herein, we have proceeded with a comprehensive review focusing on the aggregation-based analytical chemistry in POC nanosensors, covering aggregation-induced “forces”, aggregation-induced signal transductions, aggregation-induced POC nanosensing strategies, and their applications in biomolecular monitoring, food safety analysis, and environmental monitoring. Finally, challenges existing in practical applications have been further proposed to improve their sensing applications, and we expect our review can speed up the development of cost-effective, readily deployable, and time-efficient nanosensors through aggregation-based analytical chemistry.

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来源期刊
CiteScore
17.40
自引率
0.00%
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0
审稿时长
7 weeks
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