油菜素能保护雄性小鼠的大脑免受胆管结扎的有害影响

Faezeh Kouhakan, Sepideh Ganjalikhan, Alireza Sarhadizadeh, K. Esmaeilpour, Khatereh Akbari, Leila Jafaripour, Majid Asadi-Shekaari
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引用次数: 0

摘要

油菜素(OP)是橄榄中的一种酚类化合物。OP 具有强大的抗氧化活性和广泛的其他药理特性,包括抗病毒、抗炎和抗菌活性。本研究调查了 OP 对雄性小鼠胆管结扎(BDL)引起的神经损伤的影响。小鼠被随机分为三组:假组、BDL 组和 BDL + OP 组。通过神经行为测试、组织学和生化评价来评估脑损伤。结果表明,诱导 BDL 会导致行为障碍和肝酶升高,而 OP 可以保护大脑免受 BDL 引起的损伤。OP 能明显增加抗氧化酶。这些结果表明,OP 对小鼠 BDL 模型具有重要作用,这可能是由于它具有抗炎和抗氧化特性。
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Oleuropein can Protect the Brain Against Deleterious Effects of Bile Duct Ligation in Male Mice
Oleuropein (OP) is a phenolic compound in olives. OP possesses potent antioxidant activity and an extensive spectrum of other pharmacological properties, including antiviral, anti-inflammatory, and antimicrobial activities. This study investigated the effects of OP on neural injuries caused by bile duct ligation (BDL) in male mice. The mice were randomly allocated to three groups: sham, BDL, and BDL + OP. Neurobehavioral tests histological and biochemical evaluations were accomplished to assess cerebral damage. The results demonstrated that the induction of BDL led to behavioral impairments and a rise in hepatic enzymes, and OP could protect the brain against BDL-induced injuries. OP significantly increased antioxidant enzymes. These results suggested that OP has valuable effects in the mice BDL model, probably due to its anti-inflammatory and antioxidant properties.
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