Petra Bachanová, Joan How, Richard Dzeng, Sonia Mukherjee, Maia Pavlovic, Jennifer Lombardi, Gabriela Hobbs, Patrick M. Reeves
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引用次数: 0
摘要
骨髓增生性肿瘤 (MPN) 与免疫失调和感染易感性增高有关,因此强调了为患者接种疫苗的重要性。这项试验性研究使用质细胞计数法和血清学方法评估了 MPN 患者与健康供体相比对流感疫苗接种的免疫反应。我们观察到 MPN 患者的 CXCR5+ B 细胞、CXCR3+ T 细胞、活化的 CD127+ 记忆 T 细胞亚群减少,血凝素抑制滴度呈降低趋势。这些结果表明,MPN 患者对流感疫苗接种表现出不同的反应,这表明他们向淋巴器官的迁移和 T 细胞成熟受到了影响,可能会影响保护性免疫的发展。
Immune profiling of responses to influenza vaccination in patients with myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are associated with immune dysregulation and increased susceptibility to infection, emphasizing the importance of vaccination for patients. This pilot study evaluated immune responses to influenza vaccination in MPN patients compared with healthy donors using mass cytometry and serology. We observed diminished CXCR5+ B-cell, CXCR3+ T-cell, activated CD127+ memory T-cell subsets, and a trend toward lower hemagglutinin inhibition titer in MPN patients. These results indicate that patients with MPN exhibit distinct responses to influenza vaccination suggestive of impaired migration to lymphoid organs and T-cell maturation which may impact the development of protective immunity.