平展脂质分子对脂质双分子层润滑作用的影响

IF 3.1 3区 工程技术 Q2 ENGINEERING, MECHANICAL Lubricants Pub Date : 2024-04-05 DOI:10.3390/lubricants12040120
Di Jin, Jacob Klein
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引用次数: 0

摘要

髋关节和膝关节等主要滑膜关节中的关节软骨具有出色的润滑性,对关节的健康至关重要,这要归功于软骨外表面的脂质边界层,其高度水合的外露头基通过水合润滑机制产生极低的摩擦力。然而,迄今为止,还没有人考虑过自发存在的脂质飞溅--在每个对立的双分子层中都有一个酰基尾部的脂质--在调节脂质双分子层之间的摩擦力方面所起的作用。在本研究中,我们进行了全原子分子动力学模拟,以定量评估在润滑脂质双分子层框架内的分子伸展的重要性。我们证明,尽管是瞬时的,但飞溅分子会显著增加膜间摩擦力,直到它们缩回到薄片阶段,这种效应在较低的滑动速度下会更稳定地发生,与滑动关节软骨的生理速度相当。
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The Effects of Splayed Lipid Molecules on Lubrication by Lipid Bilayers
The outstanding lubrication of articular cartilage in the major synovial joints such as hips and knees, essential for the joint well-being, has been attributed to boundary layers of lipids at the outer cartilage surfaces, which have very low friction mediated by the hydration lubrication mechanism at their highly hydrated exposed headgroups. However, the role of spontaneously present lipid splays—lipids with an acyl tail in each of the opposing bilayers—in modulating the frictional force between lipid bilayers has not, to date, been considered. In this study, we perform all-atom molecular dynamics simulations to quantitatively assess the significance of splayed molecules within the framework of lubricating lipid bilayers. We demonstrate that, although transient, splayed molecules significantly increase the inter-membrane friction until their retraction back into the lamellar phase, with this effect more steadily occurring at lower sliding velocities that are comparable to the physiological velocities of sliding articular cartilage.
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来源期刊
Lubricants
Lubricants Engineering-Mechanical Engineering
CiteScore
3.60
自引率
25.70%
发文量
293
审稿时长
11 weeks
期刊介绍: This journal is dedicated to the field of Tribology and closely related disciplines. This includes the fundamentals of the following topics: -Lubrication, comprising hydrostatics, hydrodynamics, elastohydrodynamics, mixed and boundary regimes of lubrication -Friction, comprising viscous shear, Newtonian and non-Newtonian traction, boundary friction -Wear, including adhesion, abrasion, tribo-corrosion, scuffing and scoring -Cavitation and erosion -Sub-surface stressing, fatigue spalling, pitting, micro-pitting -Contact Mechanics: elasticity, elasto-plasticity, adhesion, viscoelasticity, poroelasticity, coatings and solid lubricants, layered bonded and unbonded solids -Surface Science: topography, tribo-film formation, lubricant–surface combination, surface texturing, micro-hydrodynamics, micro-elastohydrodynamics -Rheology: Newtonian, non-Newtonian fluids, dilatants, pseudo-plastics, thixotropy, shear thinning -Physical chemistry of lubricants, boundary active species, adsorption, bonding
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