Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì
{"title":"一名表皮生长因子受体基因突变（p.R776H）患者患有多种肺癌，并携带不同的体细胞表皮生长因子受体基因突变。","authors":"Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì","doi":"10.1016/j.cllc.2024.04.007","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>•</span><span><p>There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.</p></span></li><li><span>•</span><span><p>The presence of different <em>EGFR</em> mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.</p></span></li><li><span>•</span><span><p>The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.</p></span></li></ul></div>","PeriodicalId":10490,"journal":{"name":"Clinical lung cancer","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1525730424000500/pdfft?md5=3fc1e0067224b967458ed5d35f33c257&pid=1-s2.0-S1525730424000500-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations\",\"authors\":\"Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì\",\"doi\":\"10.1016/j.cllc.2024.04.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>•</span><span><p>There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.</p></span></li><li><span>•</span><span><p>The presence of different <em>EGFR</em> mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.</p></span></li><li><span>•</span><span><p>The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.</p></span></li></ul></div>\",\"PeriodicalId\":10490,\"journal\":{\"name\":\"Clinical lung cancer\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1525730424000500/pdfft?md5=3fc1e0067224b967458ed5d35f33c257&pid=1-s2.0-S1525730424000500-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical lung cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1525730424000500\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical lung cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525730424000500","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations
•
There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.
•
The presence of different EGFR mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.
•
The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.
期刊介绍：
Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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