Li-Guo Zheng , You-Yan Chen , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , Yi-Hao Lo , Yu-Chi Tsai , Hao-Chun Hu , You-Ying Chen , Tsong-Long Hwang , Tzu-Ming Ou , Ping-Jyun Sung
{"title":"从 Lendenfeldia 属海绵中分离出 24-homoscalarane 酯类化合物","authors":"Li-Guo Zheng , You-Yan Chen , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , Yi-Hao Lo , Yu-Chi Tsai , Hao-Chun Hu , You-Ying Chen , Tsong-Long Hwang , Tzu-Ming Ou , Ping-Jyun Sung","doi":"10.1016/j.phytol.2024.04.013","DOIUrl":null,"url":null,"abstract":"<div><p>The chemical screening of an algae-containing marine sponge identified as <em>Lendenfeldia</em> species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (<strong>1</strong>) and a new analogue, lendenfeldarane V (<strong>2</strong>). The structure of <strong>1</strong>, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of <strong>2</strong> was ascertained via 2D NMR experiments and a literature review. The absolute configurations of <strong>1</strong> and <strong>2</strong> were delineated with DP4+ computation and specific optical rotation. Homoscalarane <strong>1</strong> exhibited cytotoxicity towards MG63 human osteosarcoma cells.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 177-181"},"PeriodicalIF":1.3000,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia\",\"authors\":\"Li-Guo Zheng , You-Yan Chen , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , Yi-Hao Lo , Yu-Chi Tsai , Hao-Chun Hu , You-Ying Chen , Tsong-Long Hwang , Tzu-Ming Ou , Ping-Jyun Sung\",\"doi\":\"10.1016/j.phytol.2024.04.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The chemical screening of an algae-containing marine sponge identified as <em>Lendenfeldia</em> species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (<strong>1</strong>) and a new analogue, lendenfeldarane V (<strong>2</strong>). The structure of <strong>1</strong>, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of <strong>2</strong> was ascertained via 2D NMR experiments and a literature review. The absolute configurations of <strong>1</strong> and <strong>2</strong> were delineated with DP4+ computation and specific optical rotation. Homoscalarane <strong>1</strong> exhibited cytotoxicity towards MG63 human osteosarcoma cells.</p></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"61 \",\"pages\":\"Pages 177-181\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024000685\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024000685","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia
The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
