pembrolizumab辅助治疗可提高RCC患者的总生存率

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-04-29 DOI:10.1038/s41571-024-00901-2
Peter Sidaway
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引用次数: 0

摘要

在III期KEYNOTE-564试验中,与安慰剂相比,抗PD-1抗体pembrolizumab的辅助治疗可显著改善切除的非转移性中高危肾细胞癌(RCC)患者的无病生存期(DFS)。现在,这项试验的最新进展证实,pembrolizumab也能改善总生存期(OS)。共有994名患者被随机分配(1:1)接受pembrolizumab或安慰剂治疗。OS 是次要终点。此前,以24个月为分界点,DFS(主要终点)的改善具有统计学意义。
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Adjuvant pembrolizumab improves overall survival in patients with RCC
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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