{"title":"抗 SARS-CoV-2 药物 Ensitrelvir 合成策略综述","authors":"Yuanchang Liu, Gaorong Wu, Yiting Yang, Wei Hu, Xiaopeng Peng, Zihan Peng, Jiatao Xia, Xin Xie, Jiuzhong Huang* and Weiming Chen*, ","doi":"10.1021/acs.oprd.3c00494","DOIUrl":null,"url":null,"abstract":"<p >The outbreak and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to one of the most serious public health crises since the beginning of the 21st century. An oral anti-SARS-CoV-2 drug ensitrelvir was developed with satisfactory antiviral effect and was synthesized via different strategies. This Review summarizes the advantages and disadvantages of the currently reported synthetic strategies for ensitrelvir along with three related key building blocks derivatives from the view of procedure, yield, impurities, safety, and environment. This will provide a novel perspective for further process development and drug discovery.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comprehensive Review on the Synthetic Strategies toward Anti-SARS-CoV-2 Drug Ensitrelvir\",\"authors\":\"Yuanchang Liu, Gaorong Wu, Yiting Yang, Wei Hu, Xiaopeng Peng, Zihan Peng, Jiatao Xia, Xin Xie, Jiuzhong Huang* and Weiming Chen*, \",\"doi\":\"10.1021/acs.oprd.3c00494\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The outbreak and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to one of the most serious public health crises since the beginning of the 21st century. An oral anti-SARS-CoV-2 drug ensitrelvir was developed with satisfactory antiviral effect and was synthesized via different strategies. This Review summarizes the advantages and disadvantages of the currently reported synthetic strategies for ensitrelvir along with three related key building blocks derivatives from the view of procedure, yield, impurities, safety, and environment. This will provide a novel perspective for further process development and drug discovery.</p>\",\"PeriodicalId\":55,\"journal\":{\"name\":\"Organic Process Research & Development\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Process Research & Development\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.oprd.3c00494\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.oprd.3c00494","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Comprehensive Review on the Synthetic Strategies toward Anti-SARS-CoV-2 Drug Ensitrelvir
The outbreak and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to one of the most serious public health crises since the beginning of the 21st century. An oral anti-SARS-CoV-2 drug ensitrelvir was developed with satisfactory antiviral effect and was synthesized via different strategies. This Review summarizes the advantages and disadvantages of the currently reported synthetic strategies for ensitrelvir along with three related key building blocks derivatives from the view of procedure, yield, impurities, safety, and environment. This will provide a novel perspective for further process development and drug discovery.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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