探索中国广州个体葡萄糖-6-磷酸脱氢酶活性的适当参考区间和临床决策限。

IF 4 2区医学 Q1 MEDICAL LABORATORY TECHNOLOGY Annals of Laboratory Medicine Pub Date : 2024-05-03 DOI:10.3343/alm.2023.0477

Zhenyi Huang, Ziyan Li, Yating Li, Yunshan Cao, Suping Zhong, Jinlu Liu, Zhiqian Lin, Lijuan Lin, Yanping Fang, Jing Zeng, Zhaoying Su, Huibin Li, Jianfen Liang, Biqing Zhu, Zipei Lin, Yongxin Huang, Xuexi Yang, Lingxiao Jiang

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引用次数: 0

摘要

葡萄糖-6-磷酸脱氢酶（G6PD）的定量检测通常用于筛查 G6PD 缺乏症。然而，目前的 G6PD 参考区间 (RI) 并不适合评估当地人群的 G6PD 活性水平，也不适合将 G6PD 变异与溶血风险联系起来以帮助临床决策。我们研究了中国广州人 G6PD 活性的适当 RIs 和临床决策限值 (CDL)。

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Exploring Appropriate Reference Intervals and Clinical Decision Limits for Glucose-6-Phosphate Dehydrogenase Activity in Individuals From Guangzhou, China.

Quantitative detection of glucose-6-phosphate dehydrogenase (G6PD) is commonly done to screen for G6PD deficiency. However, current reference intervals (RIs) of G6PD are unsuitable for evaluating G6PD-activity levels with local populations or associating G6PD variants with hemolysis risk to aid clinical decision-making. We explored appropriate RIs and clinical decision limits (CDLs) for G6PD activity in individuals from Guangzhou, China.

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来源期刊

Annals of Laboratory Medicine MEDICAL LABORATORY TECHNOLOGY-

CiteScore

8.30

自引率

12.20%

发文量

100

审稿时长

6-12 weeks

期刊介绍： Annals of Laboratory Medicine is the official journal of Korean Society for Laboratory Medicine. The journal title has been recently changed from the Korean Journal of Laboratory Medicine (ISSN, 1598-6535) from the January issue of 2012. The JCR 2017 Impact factor of Ann Lab Med was 1.916.