影响心肌再生的结构、血管生成和免疫反应:熔炉一瞥

IF 6.4 1区 医学 Q1 CELL & TISSUE ENGINEERING npj Regenerative Medicine Pub Date : 2024-04-30 DOI:10.1038/s41536-024-00357-z
Basil M. Baccouche, Stefan Elde, Hanjay Wang, Y. Joseph Woo
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引用次数: 0

摘要

完全的心脏再生仍然是一个难以实现的治疗目标。尽管心肌细胞增殖(尤其是新生哺乳动物的心肌细胞增殖)一直备受关注,但最近的研究发现了非心肌细胞(如内皮细胞、成纤维细胞、巨噬细胞和其他免疫细胞)在调节损伤心脏再生能力方面发挥关键作用的机制。然而,人们对这些细胞类型对心脏再生的影响程度仍不甚了解。本综述将重点介绍这些非心肌细胞的作用及其各自对心脏再生的贡献,重点是新生儿期心脏损伤后的自然心脏再生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible

Complete cardiac regeneration remains an elusive therapeutic goal. Although much attention has been focused on cardiomyocyte proliferation, especially in neonatal mammals, recent investigations have unearthed mechanisms by which non-cardiomyocytes, such as endothelial cells, fibroblasts, macrophages, and other immune cells, play critical roles in modulating the regenerative capacity of the injured heart. The degree to which each of these cell types influence cardiac regeneration, however, remains incompletely understood. This review highlights the roles of these non-cardiomyocytes and their respective contributions to cardiac regeneration, with emphasis on natural heart regeneration after cardiac injury during the neonatal period.

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来源期刊
npj Regenerative Medicine
npj Regenerative Medicine Engineering-Biomedical Engineering
CiteScore
10.00
自引率
1.40%
发文量
71
审稿时长
12 weeks
期刊介绍: Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.
期刊最新文献
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