宫颈癌精准医疗的新兴生物标记物和分子靶标

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-01 DOI:10.1016/j.bbcan.2024.189106
Pankaj Garg , Madhu Krishna , Ayalur Raghu Subbalakshmi , Sravani Ramisetty , Atish Mohanty , Prakash Kulkarni , David Horne , Ravi Salgia , Sharad S. Singhal
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引用次数: 0

摘要

宫颈癌仍然是全球重大的健康负担,需要创新方法来改进诊断和个性化治疗策略。精准医疗已成为一种大有可为的模式,它利用生物标记物和分子靶点为患者量身定制治疗方案。本综述探讨了宫颈癌中新出现的生物标记物和分子靶点,强调了它们对精准医疗的潜在影响。通过将这些生物标志物整合到综合诊断算法中,临床医生可以在早期识别高危患者,从而及时干预并改善患者预后。此外,特定分子靶点的确定也为开发旨在破坏宫颈癌发生关键途径的靶向疗法铺平了道路。总之,生物标记物和分子靶点的不断发展为推进宫颈癌的精准医疗提供了令人兴奋的机遇。通过利用这些洞察力,临床医生可以优化治疗选择,改善患者预后,并最终改变这种毁灭性疾病的治疗方法。
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Emerging biomarkers and molecular targets for precision medicine in cervical cancer

Cervical cancer remains a significant global health burden, necessitating innovative approaches for improved diagnostics and personalized treatment strategies. Precision medicine has emerged as a promising paradigm, leveraging biomarkers and molecular targets to tailor therapy to individual patients. This review explores the landscape of emerging biomarkers and molecular targets in cervical cancer, highlighting their potential implications for precision medicine. By integrating these biomarkers into comprehensive diagnostic algorithms, clinicians can identify high-risk patients at an earlier stage, enabling timely intervention and improved patient outcomes. Furthermore, the identification of specific molecular targets has paved the way for the development of targeted therapies aimed at disrupting key pathways implicated in cervical carcinogenesis. In conclusion, the evolving landscape of biomarkers and molecular targets presents exciting opportunities for advancing precision medicine in cervical cancer. By harnessing these insights, clinicians can optimize treatment selection, enhance patient outcomes, and ultimately transform the management of this devastating disease.

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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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