实验性脑震荡后急性轴突病变程度的性别差异

IF 9.3 1区 医学 Q1 CLINICAL NEUROLOGY Acta Neuropathologica Pub Date : 2024-05-05 DOI:10.1007/s00401-024-02735-9
Hailong Song, Alexandra Tomasevich, Andrew Paolini, Kevin D. Browne, Kathryn L. Wofford, Brian Kelley, Eashwar Kantemneni, Justin Kennedy, Yue Qiu, Andrea L. C. Schneider, Jean-Pierre Dolle, D. Kacy Cullen, Douglas H. Smith
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引用次数: 0

摘要

虽然与男性相比,女性发生脑震荡的风险似乎更高,结果也更糟糕,但其潜在机制仍不清楚。随着越来越多的人认识到白质轴突损伤是脑震荡的一个关键病理基础,我们利用与临床相关的猪脑震荡模型来探讨轴突病变程度的潜在性别差异。受伤后24小时,雌性猪比雄性猪显示出更多的轴突肿胀轮廓和更广泛的轴突钠通道缺失。雌猪和雄猪的轴突退化似乎都与个体轴突结构有关,这反映在脑震荡后小口径轴突的选择性丢失上。然而,与男性相比,女性大脑中的小口径轴突比例更高,导致受伤后轴突损失更广泛。因此,轴突大小的性别二形性与女性脑震荡后更广泛的轴突病理学有关,这可能会导致更糟糕的后果。
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Sex differences in the extent of acute axonal pathologies after experimental concussion

Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With increasing recognition that damage to white matter axons is a key pathologic substrate of concussion, we used a clinically relevant swine model of concussion to explore potential sex differences in the extent of axonal pathologies. At 24 h post-injury, female swine displayed a greater number of swollen axonal profiles and more widespread loss of axonal sodium channels than males. Axon degeneration for both sexes appeared to be related to individual axon architecture, reflected by a selective loss of small caliber axons after concussion. However, female brains had a higher percentage of small caliber axons, leading to more extensive axon loss after injury compared to males. Accordingly, sexual dimorphism in axonal size is associated with more extensive axonal pathology in females after concussion, which may contribute to worse outcomes.

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来源期刊
Acta Neuropathologica
Acta Neuropathologica 医学-病理学
CiteScore
23.70
自引率
3.90%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Acta Neuropathologica publishes top-quality papers on the pathology of neurological diseases and experimental studies on molecular and cellular mechanisms using in vitro and in vivo models, ideally validated by analysis of human tissues. The journal accepts Original Papers, Review Articles, Case Reports, and Scientific Correspondence (Letters). Manuscripts must adhere to ethical standards, including review by appropriate ethics committees for human studies and compliance with principles of laboratory animal care for animal experiments. Failure to comply may result in rejection of the manuscript, and authors are responsible for ensuring accuracy and adherence to these requirements.
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