测定各种基质中二肽基肽酶-4 抑制剂的分析和生物分析方法:全面综述。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-05-03 DOI:10.2174/0115733998288292240409060854
Sakshi Hadawale, Sanjay Sharma
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引用次数: 0

摘要

背景:DPP-4 抑制剂或格列汀类药物是治疗 2 型糖尿病的新型口服抗糖尿病药物。它们有助于调节胰岛素和胰高血糖素。与其他一些糖尿病药物相比,这类药物的优点是低血糖风险较低,通常在二甲双胍和磺脲类药物疗效不佳时处方:本综述分析了一系列 DPP-4 抑制剂的分析和生物分析方法,这些方法使用光谱技术、色谱技术和联用技术进行分析。迄今为止,还没有包含所有 DPP-4 抑制剂的综述。本综述的主要目的是向分析人员介绍用于定量和估算不同基质中 DPP-4 抑制剂的各种分析和生物分析方法:为了加深理解,我们从 ScienceDirect 和 PubMed 等数字资源中创建了一个已有研究数据库,从而进行了综述。方法见文献选择流程图:对 DPP-4 抑制剂分析方法的全面评估可以成为研究人员和医疗从业人员的宝贵资源。迄今为止,还没有包含所有 DPP-4 抑制剂的综述。因此,在收集某一特定结构的数据时,需要对某一特定主题的现有数据进行填补。综述表明,色谱技术主要用于分析,其中乙腈、甲醇和缓冲溶液等溶剂被用作流动相,而这些流动相会损坏高效液相色谱柱和设备。因此,科学家们可以研究使用更环保溶剂评估 DPP-4 抑制剂的新方法。
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Analytical and Bioanalytical Methods for the Determination of Dipeptidyl Peptidase-4 Inhibitors in Various Matrices: A Comprehensive Review.

Background: DPP-4 inhibitors, or gliptins, are new oral antidiabetic drugs for type 2 diabetes. They help to regulate insulin and glucagon. These drugs have the advantage of a lower risk of hypoglycemia compared to some other diabetes medications and are typically prescribed when metformin and sulphonylureas have become less effective.

Objective: This review analyses a range of analytical and bioanalytical methods for DPP-4 inhibitors, that use spectroscopic techniques, chromatographic, and hyphenated techniques for analysis. So far, no review comprising all DPP-4 inhibitors has been presented. The primary objective of this review is to present the analysts with various analytical and bioanalytical methods for the quantification and estimation of DPP-4 inhibitors in different matrices.

Methods: To improve understanding, a review was carried out by creating a database of pre-existing research from digital sources such as ScienceDirect, and PubMed. The methodology is shown in the flowchart of the literature selection process.

Conclusion: The comprehensive assessment of methods for analysing DPP-4 inhibitors can be a valuable resource for researchers and healthcare practitioners. Hitherto, no review encompassing all DPP-4 inhibitors has been presented. Therefore, gaps in the data available on a particular subject, need to be required to collect data on a particular construct. The review suggests that chromatographic techniques were majorly used for analysis wherein solvents like acetonitrile, methanol, and buffer solutions were used as mobile phases that can deteriorate HPLC columns and equipment. So, scientists could investigate new methods for the assessment of DPP-4 inhibitors using more eco-friendly solvents.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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