Süleyman Oktar, Mahinur Karadeniz, Musa Acar, İsmail Zararsız
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引用次数: 0
摘要
研究了乙醇对大脑皮层的毒性作用以及欧米伽-3 脂肪酸对这种神经毒性的保护作用。28只雄性Wistar-albino大鼠被分为4组。乙醇组和乙醇戒断组大鼠接受乙醇（6 克/千克/天）治疗 15 天。乙醇+omega-3组的动物接受omega-3脂肪酸（每天400毫克/千克）和乙醇的治疗。乙醇组大鼠的 SOD 活性低于对照组大鼠。在接受欧米伽-3 脂肪酸和乙醇治疗的大鼠中，SOD 活性有所增加。各组动物的 GSH-Px 活性和 MDA 水平相似。与对照组相比，乙醇治疗组大鼠的 NO 含量明显降低（6.45±0.24 nmol/g vs 11.05±0.53 nmol/g，p. 0.05）。
The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol.
The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol SOD, activity increased. GSH-Px activity and MDA levels in animals of all groups were similar. In ethanol treated rats NO levels significantly decreased as compared to the animals of the control group (6.45±0.24 nmol/g vs 11.05±0.53 nmol/g, p.
Biomeditsinskaya khimiyaBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍：
The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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