心血管疾病中的 Nrf2-Keap1:哪个是车,哪个是马?

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2024-09-01 Epub Date: 2024-04-30 DOI:10.1152/physiol.00015.2024
Neha Dhyani, Changhai Tian, Lie Gao, Tara L Rudebush, Irving H Zucker
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引用次数: 0

摘要

在各种类型的心血管疾病(包括心力衰竭、高血压、外周动脉疾病和中风)中,血液循环和组织中普遍存在以活性氧化物(ROS)形式存在的高水平氧化应激。核因子红细胞 2 相关因子 2(Nrf2)是一种重要而广泛的抗氧化和抗炎转录因子,可能有助于心血管疾病的发病和维持。我们回顾的研究表明,Nrf2 的下调会加剧心力衰竭、高血压和自律神经功能。最后,我们讨论了使用 Nrf2 调节作为心血管疾病和自主神经功能障碍治疗策略的潜力。
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Nrf2-Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse?

High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease including heart failure, hypertension, peripheral arterial disease, and stroke. Here we review the role of nuclear factor erythroid 2-related factor 2 (Nrf2), an important and widespread antioxidant and anti-inflammatory transcription factor that may contribute to the pathogenesis and maintenance of cardiovascular diseases. We review studies showing that downregulation of Nrf2 exacerbates heart failure, hypertension, and autonomic function. Finally, we discuss the potential for using Nrf2 modulation as a therapeutic strategy for cardiovascular diseases and autonomic dysfunction.

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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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