{"title":"帮我帮你：T 滤泡辅助细胞分化、特性和功能的新概念","authors":"Sebastian A Wellford, Pamela L Schwartzberg","doi":"10.1016/j.coi.2024.102421","DOIUrl":null,"url":null,"abstract":"<div><p>Effective high-affinity, long-term humoral immunity requires T cell help provided by a subset of differentiated CD4<sup>+</sup> T cells known as T follicular helper (Tfh) cells. Classically, Tfh cells provide contact-dependent help for the generation of germinal centers (GCs) in secondary lymphoid organs (SLOs). Recent studies have expanded the conventional definition of Tfh cells, revealing new functions, new descriptions of Tfh subsets, new factors regulating Tfh differentiation, and new roles outside of SLO GCs. Together, these data suggest that one Tfh is not equivalent to another, helping redefine our understanding of Tfh cells and their biology.</p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":null,"pages":null},"PeriodicalIF":6.6000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952791524000116/pdfft?md5=ac2f8094f3295a719b55b7d7c17c5549&pid=1-s2.0-S0952791524000116-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function\",\"authors\":\"Sebastian A Wellford, Pamela L Schwartzberg\",\"doi\":\"10.1016/j.coi.2024.102421\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Effective high-affinity, long-term humoral immunity requires T cell help provided by a subset of differentiated CD4<sup>+</sup> T cells known as T follicular helper (Tfh) cells. Classically, Tfh cells provide contact-dependent help for the generation of germinal centers (GCs) in secondary lymphoid organs (SLOs). Recent studies have expanded the conventional definition of Tfh cells, revealing new functions, new descriptions of Tfh subsets, new factors regulating Tfh differentiation, and new roles outside of SLO GCs. Together, these data suggest that one Tfh is not equivalent to another, helping redefine our understanding of Tfh cells and their biology.</p></div>\",\"PeriodicalId\":11361,\"journal\":{\"name\":\"Current Opinion in Immunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.6000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0952791524000116/pdfft?md5=ac2f8094f3295a719b55b7d7c17c5549&pid=1-s2.0-S0952791524000116-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952791524000116\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952791524000116","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
有效的高亲和力长期体液免疫需要分化的 CD4+ T 细胞亚群，即 T 滤泡辅助细胞（Tfh）提供的 T 细胞帮助。传统上，Tfh 细胞为次级淋巴器官（SLO）中生殖中心（GCs）的生成提供依赖接触的帮助。最近的研究扩展了 Tfh 细胞的传统定义，揭示了新的功能、对 Tfh 亚群的新描述、调节 Tfh 分化的新因素以及在 SLO GCs 以外的新作用。这些数据共同表明，一种 Tfh 并不等同于另一种 Tfh，有助于重新定义我们对 Tfh 细胞及其生物学的认识。
Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function
Effective high-affinity, long-term humoral immunity requires T cell help provided by a subset of differentiated CD4+ T cells known as T follicular helper (Tfh) cells. Classically, Tfh cells provide contact-dependent help for the generation of germinal centers (GCs) in secondary lymphoid organs (SLOs). Recent studies have expanded the conventional definition of Tfh cells, revealing new functions, new descriptions of Tfh subsets, new factors regulating Tfh differentiation, and new roles outside of SLO GCs. Together, these data suggest that one Tfh is not equivalent to another, helping redefine our understanding of Tfh cells and their biology.
期刊介绍：
Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students.
Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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