Qingwen Ding , Bing Hu , Xuan Yao , Min Gan , Dan Chen , Nailou Zhang , Jinbo Wei , Kun Cai , Zhenhua Zheng
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引用次数: 0
摘要
由戊型肝炎病毒（HEV）引起的戊型肝炎是一个全球性的公共卫生问题。小鼠和人类戊型肝炎病毒的基因序列相似度较低，因此人们认为人类感染的风险很低。最近有报告称，香港人感染了由小鼠戊型肝炎病毒引起的慢性和急性戊型肝炎，这引起了全球的关注。因此，调查 HEV 在中国的流行病学和患病率至关重要。我们全面分析了不同的啮齿类动物 HEV 株系，以了解中国湖北省的啮齿类动物戊型肝炎病毒发生情况。HEV阳性率为6.43%（73/1136）。我们鉴定了七种近全长的啮齿类动物巨细胞病毒毒株，并在不同种类的小鼠组织中检测到了大鼠巨细胞病毒抗原。HEV 具有广泛的组织滋养性，在肝脏中的病毒载量很高。我们强调了啮齿动物中 HEV 的遗传多样性，并强调了关注其变异和进化的重要性。
Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China
Hepatitis E, caused by the hepatitis E virus (HEV), is a global public health issue. Low similarity between the gene sequences of mouse and human HEV led to the belief that the risk of human infection was low. Recent reports of chronic and acute hepatitis E caused by murine HEV infection in humans in Hong Kong have raised global concerns. Therefore, it is crucial to investigate the epidemiology and prevalence of HEV in China. We comprehensively analyzed different rodent HEV strains to understand rocahepevirus occurrence in Hubei Province, China. The HEV positivity rate for was 6.43% (73/1136). We identified seven near-full-length rocahepevirus strains and detected rat HEV antigens in tissues from different mouse species. HEV has extensive tissue tropism and a high viral load in the liver. We highlight the genetic diversity of HEVs in rodents and underscore the importance of paying attention to their variation and evolution.
期刊介绍：
(aka Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases -- MEEGID)
Infectious diseases constitute one of the main challenges to medical science in the coming century. The impressive development of molecular megatechnologies and of bioinformatics have greatly increased our knowledge of the evolution, transmission and pathogenicity of infectious diseases. Research has shown that host susceptibility to many infectious diseases has a genetic basis. Furthermore, much is now known on the molecular epidemiology, evolution and virulence of pathogenic agents, as well as their resistance to drugs, vaccines, and antibiotics. Equally, research on the genetics of disease vectors has greatly improved our understanding of their systematics, has increased our capacity to identify target populations for control or intervention, and has provided detailed information on the mechanisms of insecticide resistance.
However, the genetics and evolutionary biology of hosts, pathogens and vectors have tended to develop as three separate fields of research. This artificial compartmentalisation is of concern due to our growing appreciation of the strong co-evolutionary interactions among hosts, pathogens and vectors.
Infection, Genetics and Evolution and its companion congress [MEEGID](http://www.meegidconference.com/) (for Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases) are the main forum acting for the cross-fertilization between evolutionary science and biomedical research on infectious diseases.
Infection, Genetics and Evolution is the only journal that welcomes articles dealing with the genetics and evolutionary biology of hosts, pathogens and vectors, and coevolution processes among them in relation to infection and disease manifestation. All infectious models enter the scope of the journal, including pathogens of humans, animals and plants, either parasites, fungi, bacteria, viruses or prions. The journal welcomes articles dealing with genetics, population genetics, genomics, postgenomics, gene expression, evolutionary biology, population dynamics, mathematical modeling and bioinformatics. We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .
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