人类乳头瘤病毒(hpv)与膀胱癌诊断之间的关联:系统回顾与荟萃分析。

I.J. Otero-Muriel , S. Jiménez Giraldo , H.A. García-Perdomo
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引用次数: 0

摘要

背景:膀胱癌(BC)是全球第七大常见癌症:膀胱癌(BC)是全球第七大常见癌症。尽管人乳头瘤病毒(HPV)诱发的癌变是一个复杂的炎症过程,但并非所有感染都会导致癌症。为了确定人类乳头瘤病毒(HPV)与膀胱癌诊断之间的关联:方法:我们根据 Cochrane 和 PRISMA 建议进行了系统性回顾。我们检索了 EMBASE、Medline (Ovid) 和 Cochrane 对照试验中央注册中心 (CENTRAL),检索时间从开始到现在。我们纳入了病例对照研究。偏倚风险评估基于 QUADAS2 进行。我们进行了随机效应 Meta 分析:我们对 14 项研究进行了定性和定量分析。主要存在低偏倚风险。我们最终发现,HPV 的存在与膀胱癌诊断之间存在密切联系(OR 4.18 95%CI 2.63 至 6.66;I2 = 40%):目前,HPV 与膀胱癌的诊断有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The association between the human papillomavirus (HPV) and the diagnosis of bladder cancer: systematic review and meta-analysis

Background

Bladder cancer (BC) is the seventh most common cancer worldwide. Not every infection ends as cancer, although the HPV-induced carcinogenesis is a complex process consequence of inflammation. To determine the association between human papillomavirus (HPV) and the diagnosis of bladder cancer.

Methods

We carried out a systematic review according to Cochrane and PRISMA recommendations. We searched in EMBASE, Medline (Ovid), and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included case-control studies. The risk of bias assessment was performed based on QUADAS2. We performed a random effect Meta-analysis.

Results

We included 14 studies in qualitative and quantitative analysis. There was mainly a low risk of bias. We finally found a strong association between the presence of HPV and bladder cancer diagnosis (OR 4.18 95%CI 2.63–6.66; I2 = 40%).

Conclusions

HPV is currently associated with the diagnosis of bladder cancer.

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