Tong Liu, Zhiting Zhang, Yihan Tian, Yanhui Ji, Wei Li
{"title":"接受131I治疗的分化型甲状腺癌术后患者甲状旁腺功能的长期影响和永久性甲状旁腺功能减退症的风险因素：临床数据的回顾性分析","authors":"Tong Liu, Zhiting Zhang, Yihan Tian, Yanhui Ji, Wei Li","doi":"10.1007/s40336-024-00634-3","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study aims to explore the long-term effects on parathyroid function and risk factors associated with permanent hypoparathyroidism (HPT) in differentiated thyroid cancer (DTC) patients treated with <sup>131</sup>I.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>201 postoperative DTC patients were included. Serum levels of parathyroid hormone (PTH), 25-hydroxyvitamin D (25-OH-VD), calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) were collected before (baseline) and after <sup>131</sup>I treatment. Patients were divided into permanent HPT group and non-permanent HPT group, and risk factors were analyzed using penalized logistic regression (PLR).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>There were no statistically significant differences in serum levels of PTH, 25-OH-VD, Ca, P, and ALP among the five time points (baseline, 6 months, 12 months, 24 months, and 36 months) (<i>P</i> > 0.05). Multivariate PLR analysis revealed that the presence of functional metastases in the first <sup>131</sup>I-SPECT/CT-whole-body scan (<sup>131</sup>I-WBS) was a significant risk factor for permanent HPT (OR = 21.392, <i>P</i> < 0.05).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Postoperative <sup>131</sup>I therapy for DTC has no significant adverse effects on the parathyroid function within three years, but extremely few patients still develop permanent HPT, with an increased risk in those with functional metastases in the first <sup>131</sup>I-WBS.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term effects on parathyroid function and risk factors for permanent hypoparathyroidism in post-surgical differentiated thyroid cancer patients treated with 131I: a retrospective analysis of clinical data\",\"authors\":\"Tong Liu, Zhiting Zhang, Yihan Tian, Yanhui Ji, Wei Li\",\"doi\":\"10.1007/s40336-024-00634-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>This study aims to explore the long-term effects on parathyroid function and risk factors associated with permanent hypoparathyroidism (HPT) in differentiated thyroid cancer (DTC) patients treated with <sup>131</sup>I.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>201 postoperative DTC patients were included. Serum levels of parathyroid hormone (PTH), 25-hydroxyvitamin D (25-OH-VD), calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) were collected before (baseline) and after <sup>131</sup>I treatment. Patients were divided into permanent HPT group and non-permanent HPT group, and risk factors were analyzed using penalized logistic regression (PLR).</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>There were no statistically significant differences in serum levels of PTH, 25-OH-VD, Ca, P, and ALP among the five time points (baseline, 6 months, 12 months, 24 months, and 36 months) (<i>P</i> > 0.05). Multivariate PLR analysis revealed that the presence of functional metastases in the first <sup>131</sup>I-SPECT/CT-whole-body scan (<sup>131</sup>I-WBS) was a significant risk factor for permanent HPT (OR = 21.392, <i>P</i> < 0.05).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>Postoperative <sup>131</sup>I therapy for DTC has no significant adverse effects on the parathyroid function within three years, but extremely few patients still develop permanent HPT, with an increased risk in those with functional metastases in the first <sup>131</sup>I-WBS.</p>\",\"PeriodicalId\":48600,\"journal\":{\"name\":\"Clinical and Translational Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Translational Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40336-024-00634-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40336-024-00634-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Long-term effects on parathyroid function and risk factors for permanent hypoparathyroidism in post-surgical differentiated thyroid cancer patients treated with 131I: a retrospective analysis of clinical data
Purpose
This study aims to explore the long-term effects on parathyroid function and risk factors associated with permanent hypoparathyroidism (HPT) in differentiated thyroid cancer (DTC) patients treated with 131I.
Methods
201 postoperative DTC patients were included. Serum levels of parathyroid hormone (PTH), 25-hydroxyvitamin D (25-OH-VD), calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP) were collected before (baseline) and after 131I treatment. Patients were divided into permanent HPT group and non-permanent HPT group, and risk factors were analyzed using penalized logistic regression (PLR).
Results
There were no statistically significant differences in serum levels of PTH, 25-OH-VD, Ca, P, and ALP among the five time points (baseline, 6 months, 12 months, 24 months, and 36 months) (P > 0.05). Multivariate PLR analysis revealed that the presence of functional metastases in the first 131I-SPECT/CT-whole-body scan (131I-WBS) was a significant risk factor for permanent HPT (OR = 21.392, P < 0.05).
Conclusions
Postoperative 131I therapy for DTC has no significant adverse effects on the parathyroid function within three years, but extremely few patients still develop permanent HPT, with an increased risk in those with functional metastases in the first 131I-WBS.
期刊介绍：
Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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