免疫介导的肝损伤中多反应性免疫球蛋白 G 的升高与免疫抑制疗法的必要性

Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles-Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg Gevers, Benedetta Terziroli Beretta-Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group
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引用次数: 0

摘要

背景和目的 由于药物性肝损伤(DILI)、药物性自身免疫性肝炎(DI-ALH)和自身免疫性肝炎(AIH)的临床特征相互重叠,因此将它们区分开来具有挑战性。最近,多反应性免疫球蛋白 G(pIgG)被认为是一种新型生物标记物,与传统的自身抗体相比,其诊断 AIH 的准确性更高。这项回顾性多中心研究旨在评估 pIgG 在区分 AIH、DI-ALH 和 DILI 方面的诊断准确性,从而确定需要接受免疫抑制的患者。
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Elevated polyreactive immunoglobulin G in immune mediated liver injuries with the need for immunosuppressive therapy
Background and aim The distinction of drug-induced liver injury (DILI), drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker with a higher accuracy for the diagnose of AIH than conventional autoantibodies. This retrospective multicenter study aimed to evaluate the diagnostic accuracy of pIgG to distinguish between AIH, DI-ALH and DILI and thus identify patients in need of immunosuppression.
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