评估西布曲霉对 CCl4 引起的大鼠肝损伤的保肝作用

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI:10.1615/intjmedmushrooms.2024053967
Amirhossein Sarkar, Omid Sabzevari, Seyed Esmaeil Sadat Ebrahimi, Sana Shahnazari, Reza Asadollahi Rad, Mahdi Vazirian
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引用次数: 0

摘要

人类使用蘑菇作为药物已有 5000 多年的历史。如今,从药用蘑菇中提取的一些提取物和化合物在调节免疫系统、抑制癌症、心血管健康、抗病毒、抗菌、抗氧化以及对肝炎和糖尿病的保护作用等方面发挥着重要作用,因而在治疗多种疾病方面具有广阔的前景。为了评估蘑菇不同提取物的抗氧化性,采用了 DPPH 法。为了评估蘑菇的肝脏保护特性,设计了一个为期七天的实验,用四氯化碳诱导肝脏中毒(连续七天腹腔注射/ip,0.5 毫升/千克体重)。同时给大鼠喂食剂量为 250、500 和 1000 毫克/千克体重的蘑菇水提取物,以及作为阳性对照的水飞蓟素(100 毫克/千克体重)。实验结束时,对主要肝脏因子(如谷草转氨酶、谷丙转氨酶、谷草转氨酶、胆红素)进行量化。水提取物显示出更强的自由基清除活性(IC50=414.33 µg/ml,而甲醇提取物为 936.92 µg/ml)。事实上,蘑菇水提取物的保肝特性与水飞蓟素相当,甚至在组织病理学检查中显示出更强的保护作用。看来,通过进一步的补充研究,刺五加蘑菇可被视为一种潜在的肝脏保护候选物质。
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Evaluation of hepatoprotective effect of Trametes gibbosa on CCl4-induced liver injury in rats
Mushrooms have been used as medicine by humans for more than 5,000 years. Nowadays, some extracts and compounds obtained from medicinal mushrooms have increased a great prospect of treating many disorders by having a great role in modulation of immune system, cancer inhibiting, cardio-vascular health, antiviral, antibacterial, antioxidant and protective effects against hepatitis and diabetes. In this study, we evaluated the antioxidant effect of methanol and hot water extract of the Trametes gibbosa (Pers.) Fr. mushroom and hepatoprotective effect of the extract with the most radical scavenging potency. To assess the antioxidant properties of different extracts of the mushroom, DPPH method was used. For assessing the hepatoprotective properties, a seven-day experiment was designed and liver toxicity was induced by carbon tetrachloride (intraperitoneal/ip for seven consecutive days, 0.5 ml/kg BW). Rats were simultaneously fed with aqueous extract of the mushroom with the dose of 250, 500 and 1000 mg/kg BW and silymarin (100 mg/kg BW) as positive control. At the end of the experiment, major liver factors (e.g., AST, ALT, ALP, bilirubin) were quantified. Tissue samples were obtained for pathological examination. Aqueous extract showed more potent radical scavenging activity (IC50=414.33 µg/ml, compared to 936.92 µg/ml for methanolic extract). Indeed, hepatoprotective properties of the aqueous extract of the mushroom were comparable with those of silymarin and even showed superior protective effects in histopathological examination. It seems that with further complementary studies, T. gibbosa could be considered a potential candidate for hepatoprotection.
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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