缺氧条件下癌症相关 miRNAs 的表达调控

IF 2.6 4区医学 Q3 CELL BIOLOGY Analytical Cellular Pathology Pub Date : 2024-05-10 DOI:10.1155/2024/5523283

Jesús Valencia-Cervantes, Martha Patricia Sierra-Vargas

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引用次数: 0

摘要

实体瘤经常会出现缺氧或低氧水平。在这种情况下，低氧诱导因子 1α（HIF-1α）被激活，并作为一种转录因子调节癌细胞对氧气和营养匮乏的适应。HIF-1α 可控制与促进癌细胞增殖和存活的各种信号通路相关的基因表达。微小核糖核酸（miRNA）是 22 个核苷酸的非编码 RNA，在癌症进展所必需的各种生物过程中发挥作用。本综述概述了缺氧如何调控多种 miRNA 在癌细胞进展过程中的表达。

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Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions

Solid tumors frequently experience hypoxia or low O₂ levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O₂ and nutrient deprivation. HIF-1α controls gene expression associated with various signaling pathways that promote cancer cell proliferation and survival. MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs that play a role in various biological processes essential for cancer progression. This review presents an overview of how hypoxia regulates the expression of multiple miRNAs in the progression of cancer cells.

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来源期刊

Analytical Cellular Pathology ONCOLOGY-CELL BIOLOGY

CiteScore

4.90

自引率

3.10%

发文量

审稿时长

16 weeks

期刊介绍： Analytical Cellular Pathology is a peer-reviewed, Open Access journal that provides a forum for scientists, medical practitioners and pathologists working in the area of cellular pathology. The journal publishes original research articles, review articles, and clinical studies related to cytology, carcinogenesis, cell receptors, biomarkers, diagnostic pathology, immunopathology, and hematology.