Ines Horvat-Menih, Ruth Casey, James Denholm, Gregory Hamm, Heather Hulme, John Gallon, Alixander S Khan, Joshua Kaggie, Andrew B Gill, Andrew N Priest, Joao A G Duarte, Cissy Yong, Cara Brodie, James Whitworth, Simon T Barry, Richard J A Goodwin, Shubha Anand, Marc Dodd, Katherine Honan, Sarah J Welsh, Anne Y Warren, Tevita Aho, Grant D Stewart, Thomas J Mitchell, Mary A McLean, Ferdia A Gallagher
{"title":"利用临床超极化 13C-MRI 和质谱成像技术探测富马酸氢化酶缺陷型肾癌的瘤内代谢分区","authors":"Ines Horvat-Menih, Ruth Casey, James Denholm, Gregory Hamm, Heather Hulme, John Gallon, Alixander S Khan, Joshua Kaggie, Andrew B Gill, Andrew N Priest, Joao A G Duarte, Cissy Yong, Cara Brodie, James Whitworth, Simon T Barry, Richard J A Goodwin, Shubha Anand, Marc Dodd, Katherine Honan, Sarah J Welsh, Anne Y Warren, Tevita Aho, Grant D Stewart, Thomas J Mitchell, Mary A McLean, Ferdia A Gallagher","doi":"10.1101/2024.05.06.24306817","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Probing intratumoral metabolic compartmentalisation in fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging\",\"authors\":\"Ines Horvat-Menih, Ruth Casey, James Denholm, Gregory Hamm, Heather Hulme, John Gallon, Alixander S Khan, Joshua Kaggie, Andrew B Gill, Andrew N Priest, Joao A G Duarte, Cissy Yong, Cara Brodie, James Whitworth, Simon T Barry, Richard J A Goodwin, Shubha Anand, Marc Dodd, Katherine Honan, Sarah J Welsh, Anne Y Warren, Tevita Aho, Grant D Stewart, Thomas J Mitchell, Mary A McLean, Ferdia A Gallagher\",\"doi\":\"10.1101/2024.05.06.24306817\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Background</strong> Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.\",\"PeriodicalId\":501358,\"journal\":{\"name\":\"medRxiv - Radiology and Imaging\",\"volume\":\"66 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Radiology and Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.05.06.24306817\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Radiology and Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.06.24306817","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Probing intratumoral metabolic compartmentalisation in fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging
Background Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.
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